Maternal smoking during pregnancy and offspring overweight: is there a dose–response relationship? An individual patient data meta-analysis

Albers, Lucia; Sobotzki, Christina; Kuß, Oliver; Ajslev, Teresa; Batista, Rosangela FL; Bettiol, Heloisa; Brabin, Bernard; Buka, Stephen L; Cardoso, Viviane C; Clifton, Vicki L; Devereux, Graham; Gilman, Stephen E; Grzeskowiak, Luke E; Heinrich, Joachim; Hummel, Sandra; Jacobsen, Geir W; Jones, Graeme; Koshy, Gibby; Morgen, Camilla Schmidt; Oken, Emily; Paus, Tomas; Pausova, Zdenka; Rifas-Shiman, Sheryl L; Sharma, Andrea J; da Silva, Antônio AM; Sørensen, Thorkild IA; Thiering, Elisabeth; Turner, Stephen; Vik, Torstein; von Kries, Rüdiger

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Maternal smoking during pregnancy and offspring overweight: is there a dose–response relationship? An individual patient data meta-analysis

February 28 2018
By Albers, Lucia ; Sobotzki, Christina ; Kuß, Oliver ; ...
Source: Int J Obes (Lond). 42(7):1249-1264

[PDF-1.08 MB]

English

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Details:

Alternative Title:

Int J Obes (Lond)
Personal Author:

Albers, Lucia ; Sobotzki, Christina ; Kuß, Oliver ; Ajslev, Teresa ; Batista, Rosangela FL ; ... More +

Albers, Lucia ; Sobotzki, Christina ; Kuß, Oliver ; Ajslev, Teresa ; Batista, Rosangela FL ; Bettiol, Heloisa ; Brabin, Bernard ; Buka, Stephen L ; Cardoso, Viviane C ; Clifton, Vicki L ; Devereux, Graham ; Gilman, Stephen E ; Grzeskowiak, Luke E ; Heinrich, Joachim ; Hummel, Sandra ; Jacobsen, Geir W ; Jones, Graeme ; Koshy, Gibby ; Morgen, Camilla Schmidt ; Oken, Emily ; Paus, Tomas ; Pausova, Zdenka ; Rifas-Shiman, Sheryl L ; Sharma, Andrea J ; da Silva, Antônio AM ; Sørensen, Thorkild IA ; Thiering, Elisabeth ; Turner, Stephen ; Vik, Torstein ; von Kries, Rüdiger Less -
Description:

Background/objectives

A number of meta-analyses suggest an association between any maternal smoking in pregnancy and offspring overweight obesity. Whether there is a dose–response relationship across number of cigarettes and whether this differs by sex remains unclear.

Subject/methods

Studies reporting number of cigarettes smoked during pregnancy and offspring BMI published up to May 2015 were searched. An individual patient data meta-analysis of association between the number of cigarettes smoked during pregnancy and offspring overweight (defined according to the International Obesity Task Force reference) was computed using a generalized additive mixed model with non-linear effects and adjustment for confounders (maternal weight status, breastfeeding, and maternal education) and stratification for sex.

Results

Of 26 identified studies, 16 authors provided data on a total of 238,340 mother–child-pairs. A linear positive association was observed between the number of cigarettes smoked and offspring overweight for up to 15 cigarettes per day with an OR increase per cigarette of 1.03, 95% CI = [1.02–1.03]. The OR flattened with higher cigarette use. Associations were similar in males and females. Sensitivity analyses supported these results.

Conclusions

A linear dose–response relationship of maternal smoking was observed in the range of 1–15 cigarettes per day equally in boys and girls with no further risk increase for doses above 15 cigarettes.
Subjects:

[+]

Adult Article Body Mass Index Child Child, Preschool Child Development Dose-Response Relationship, Drug Female Humans Infant Infant, Newborn Male Pediatric Obesity Pregnancy Pregnant Women Prenatal Exposure Delayed Effects Sex Distribution Smoking
Source:

Int J Obes (Lond). 42(7):1249-1264
Pubmed ID:

29717267
Pubmed Central ID:

PMC6685293
Document Type:

Journal Article
Funding:

R37 HD034568/NICHD NIH HHS/National Institute of Child Health & Human Development/United States ; 102215/2/13/2/Wellcome Trust/United Kingdom ; CC999999/Intramural CDC HHS/Intramural CDC HHS/United States ; Wellcome Trust/United Kingdom ; R01 HD034568/NICHD NIH HHS/National Institute of Child Health & Human Development/United States

R37 HD034568/NICHD NIH HHS/National Institute of Child Health & Human Development/United States ; 102215/2/13/2/Wellcome Trust/United Kingdom ; CC999999/Intramural CDC HHS/Intramural CDC HHS/United States ; Wellcome Trust/United Kingdom ; R01 HD034568/NICHD NIH HHS/National Institute of Child Health & Human Development/United States Less -
Volume:

42
Issue:

7
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:f1d45ca0c8e5f448e37c3b314e298521e768743f6def4561342c74a2c4752a64
Download URL:

https://stacks.cdc.gov/view/cdc/80590/cdc_80590_DS1.pdf
File Type:

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