Maternal Pregnancy Levels of trans-Nonachlor and Oxychlordane and Prevalence of Cryptorchidism and Hypospadias in Boys

Trabert, Britton; Longnecker, Matthew P.; Brock, John W.; Klebanoff, Mark A.; McGlynn, Katherine A.

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Maternal Pregnancy Levels of trans-Nonachlor and Oxychlordane and Prevalence of Cryptorchidism and Hypospadias in Boys

Sep 07 2011
By Trabert, Britton ; Longnecker, Matthew P. ; Brock, John W. ; ...
Source: Environ Health Perspect. 2011; 120(3):478-482.

[PDF-213.24 KB]

English

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Details:

Alternative Title:

Environ Health Perspect
Personal Author:

Trabert, Britton ; Longnecker, Matthew P. ; Brock, John W. ; Klebanoff, Mark A. ; McGlynn, Katherine A.

Trabert, Britton ; Longnecker, Matthew P. ; Brock, John W. ; Klebanoff, Mark A. ; McGlynn, Katherine A. Less -
Description:

The etiologies of the male urogenital anomalies--cryptorchidism and hypospadias--are poorly understood. Given positive associations between chlordane isomers and testicular germ cell tumors, it is reasonable to assume that chlordanes might also be associated with other testicular dysgenesis syndrome disorders, namely cryptorchidism and hypospadias.|To examine whether exposure to in utero chlordane is related to cryptorchidism and hypospadias, we evaluated levels of chlordane derivatives, trans-nonachlor and oxychlordane, among pregnant women enrolled in the Collaborative Perinatal Project (CPP).|From 1959 to 1965, the CPP enrolled pregnant women at 12 U.S. medical centers. We analyzed serum trans-nonachlor and oxychlordane levels measured in third-trimester serum from the mothers of 217 sons with cryptorchidism, 197 sons with hypospadias, and 557 sons with neither condition. Adjusted odds ratios (ORs) and 95% confidence intervals were calculated using conditional logistic regression.|The quartile-specific ORs for cryptorchidism or hypospadias show no notable associations with trans-nonachlor or oxychlordane. Further, there were no significant trends with increasing quartile of maternal trans-nonachlor or oxychlordane level in either cryptorchidism or hypospadias (p-trend all > 0.45).|The results do not support an association between chlordane levels and cryptorchidism or hypospadias. It is unlikely that current chlordane exposure is related to the development of either anomaly, given that serum chlordane levels at the time of sample collection, the early 1960s, were considerably higher than levels at present.
Subjects:

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Adult Case-Control Studies Chlordan Cohort Studies Cryptorchidism Female Humans Hydrocarbons, Chlorinated Hypospadias Insecticides Logistic Models Male Odds Ratio Pregnancy Prenatal Exposure Delayed Effects Prevalence Prospective Studies Risk Factors Young Adult
Source:

Environ Health Perspect. 2011; 120(3):478-482.
Document Type:

Journal Article
Place as Subject:

United States
Volume:

120
Issue:

3
Collection(s):

CDC Public Access
Main Document Checksum:

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urn:sha256:c1710fa20c7d254c1908cbdaede485f11d2dad62d52534a032de93a4d44be733
Download URL:

https://stacks.cdc.gov/view/cdc/8055/cdc_8055_DS1.pdf
File Type:

	ehp.1103936.nxml	txt
	license.txt	txt

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