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Antiarrhythmic mechanisms of beta blocker therapy
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May 14 2019
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Source: Pharmacol Res. 146:104274
[PDF-506.69 KB]
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Alternative Title:Pharmacol Res
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Description:Sympathetic activity plays an important role in modulation of cardiac rhythm. Indeed, while exerting positive tropic effects in response to physiologic and pathologic stressors, β-adrenergic stimulation influences cardiac electrophysiology and can lead to disturbances of the heart rhythm and potentially lethal arrhythmias, particularly in pathological settings. For this reason, β-blockers are widely utilized clinically as antiarrhythmics. In this review, the molecular mechanisms of β-adrenergic action in the heart, the cellular and tissue level cardiac responses to β-adrenergic stimulation, and the clinical use of β-blockers as antiarrhythmic agents are reviewed. We emphasize the complex interaction between cardiomyocyte signaling, contraction, and electrophysiology occurring over multiple time- and spatial-scales during pathophysiological responses to β-adrenergic stimulation. An integrated understanding of this complex system is essential for optimizing therapies aimed at preventing arrhythmias.
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Pubmed ID:31100336
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Pubmed Central ID:PMC6679787
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Funding:R01 HL111600/NHLBI NIH HHS/National Heart, Lung, and Blood Institute/United States ; OT2 OD026580/ODCDC CDC HHS/Office of the Director/United States ; OT2 OD026580/ODCDC CDC HHS/Office of the Director/United States ; 15SDG24910015/American Heart Association-American Stroke Association/United States ; R01 HL131517/NHLBI NIH HHS/National Heart, Lung, and Blood Institute/United States ; ... More +
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Volume:146
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