A GWAS-Derived Polygenic Score for Interleukin-1β is Associated with Hippocampal Volume in Two Samples

Details

• Alternative Title:
  Hum Brain Mapp
• Personal Author:
  Avinun, Reut ; Nevo, Adam ; Knodt, Annchen R. ; Elliott, Maxwell L. ; Hariri, Ahmad R.
• Description:
  Accumulating research suggests that the pro-inflammatory cytokine interleukin-1β (IL-1β) has a modulatory effect on the hippocampus, a brain structure important for learning and memory as well as linked with both psychiatric and neurodegenerative disorders. Here, we used an imaging genetics strategy to test an association between an IL-1β polygenic score and hippocampal volume in two independent samples. Our polygenic score was derived using summary statistics from a recent genome-wide association study of circulating cytokines that included IL-1β (N = 3,309). In the first sample of 512 non-Hispanic Caucasian university students (274 women, mean age 19.78 ± 1.24 years) from the Duke Neurogenetics Study, we identified a significant positive correlation between IL-1β polygenic scores and hippocampal volume. This positive association was successfully replicated in a second sample of 7,960 white British volunteers (4,158 women, mean age 62.63 ± 7.45 years) from the UK Biobank. Our results lend further support in humans, to the link between IL-1β and the structure of the hippocampus.
• Subjects:
  Adolescent Adult Aged Female Genome-Wide Association Study Hippocampus Humans Inflammation Interleukin-1beta Magnetic Resonance Imaging Male Middle Aged Young Adult

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• Keywords:
  Brain Volume Hippocampus Inflammation Interleukin-1β (IL-1 β) Polygenic Score Single Nucleotide Polymorphism Structural MRI
• Source:
  Hum Brain Mapp. 40(13):3910-3917
• Pubmed ID:
  31119842
• Pubmed Central ID:
  PMC6679724
• Document Type:
  Journal Article
• Funding:
  S10 OD018164/CD/ODCDC CDC HHSUnited States/ ; R01 AG049789/AG/NIA NIH HHSUnited States/ ; R01DA033369/US-National Institutes of HealthInternational/ ; R01 DA033369/DA/NIDA NIH HHSUnited States/ ; R01 DA031579/DA/NIDA NIH HHSUnited States/ ; R01AG049789/US-National Institutes of HealthInternational/ ; NSF DGE-1644868/National Science Foundation Graduate Research FellowshipInternational/ ; Duke UniversityInternational/ ; S10 OD021480/OD/NIH HHSUnited States/ ; S10 OD018164/OD/NIH HHSUnited States/ ; R01DA031579/US-National Institutes of HealthInternational/
• Volume:
  40
• Issue:
  13
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8a33cae4678f73f0a8abd70a4f75311a178adb0120bc62a950a15e627dd4fc8a
• Download URL:
  https://stacks.cdc.gov/view/cdc/80416/cdc_80416_DS1.pdf
• File Type:
  [PDF - 337.67 KB ]