The risk of neurodevelopmental disorders at age 10 years associated with blood concentrations of Interleukins 4 and 10 during the first postnatal month of children born extremely preterm.

Details

• Alternative Title:
  Cytokine
• Personal Author:
  Leviton, Alan ; Joseph, Robert M ; Allred, Elizabeth N ; Fichorova, Raina N ; O’Shea, T. Michael ; Kuban, Karl KC ; Dammann, Olaf
• Description:
  Background
  
  Interleukin (IL)-4 and IL-10 are viewed mainly as anti-inflammatory cytokines. Yet, high concentrations have also been associated with inflammation-related diseases in newborns.
  
  Methods
  
  We measured the concentrations of IL-4 and IL-10, as well as IL-8 and ICAM-1 in blood specimens collected on postnatal day 21 (N = 555), day 28 (N = 521), and both days 21 and 28 (N = 449) from children born extremely preterm (EP) (< 28 weeks gestation) who at age 10 years had a DAS-II IQ Z-score > −2 (which approximates a score of > 70) and the following assessments, CCC-2, and CSI-4, DAS-II, NEPSY-II, OWLS-II, SCQ, and WIAT-III. Selected children also were assessed with the ADI-R and the ADOS-2. We modeled the risk of low scores or dysfunctions associated with top quartile concentrations of IL-4 and IL-10 on each day and on both days.
  
  Results
  
  The risks of low scores on the Animal Sorting and Arrows components of the NEPSY-II, both components of the OWLS-II, and the PseudoWord and Spelling components of the WIAT-III were heightened among children who had top quartile concentrations of IL-4 on postnatal days 21 and 28. Children who had high concentrations of IL-10 on days 21 and 28, individually and collectively, were at increased risk of low scores on the WIAT-III Spelling component. High concentrations of IL-4 on day 28 were associated with autism spectrum disorder (ASD). High concentrations of IL-10 on day 28 were also associated with a doubling of ASD risk, but this did not achieve statistical significance. Top quartile concentrations of IL-4 and IL10 on both days were not associated with increased risk of social, language, or behavioral dysfunctions
  
  Conclusion
  
  Among children born EP, those who had top quartile concentrations of IL-4 and/or IL-10 on postnatal days 21 and/or 28 were more likely than their peers to have low scores on components of the NEPSY-II, OWLS-II, and WIAT-III assessments, as well as identification as having an ASD.
  
  
• Subjects:
  Article Autism Spectrum Disorder Developmental Outcome Inflammation Interleukin-4 Interleukin-10 Neurodevelopment Reading Spelling Very Premature Infant
• Source:
  Cytokine. 110:181-188
• Pubmed ID:
  29763840
• Pubmed Central ID:
  PMC6668706
• Document Type:
  Journal Article
• Funding:
  P30 HD018655/NICHD NIH HHS/National Institute of Child Health & Human Development/United States ; R01 EY021820/NEI NIH HHS/National Eye Institute/United States ; U01 NS040069/NINDS NIH HHS/National Institute of Neurological Disorders and Stroke/United States ; UG3 OD023348/ODCDC CDC HHS/Office of the Director/United States
• Volume:
  110
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a984942cf4811ae3c3ed8edc75b604d01761fdf2c55c63939aca9351f0181ba6
• Download URL:
  https://stacks.cdc.gov/view/cdc/80375/cdc_80375_DS1.pdf
• File Type:
  [PDF - 120.99 KB ]