17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Campi-Azevedo, Ana Carolina ; Peruhype-Magalhāes, Vanessa ; Coelho-dos-Reis, Jordana Grazziela ; Antonelli, Lis Ribeiro ; Costa-Pereira, Christiane ; Speziali, Elaine ; Reis, Laise Rodrigues ; Lemos, Jandira Aparecida ; Ribeiro, José Geraldo Leite ; Bastos Camacho, Luiz Antônio ; de Sousa Maia, Maria de Lourdes ; Barbosa de Lima, Sheila Maria ; Simões, Marisol ; de Menezes Martins, Reinaldo ; Homma, Akira ; Cota Malaquias, Luiz Cosme ; Tauil, Pedro Luiz ; Costa Vasconcelos, Pedro Fernando ; Martins Romano, Alessandro Pecego ; Domingues, Carla Magda ; Teixeira-Carvalho, Andréa ; Martins-Filho, Olindo Assis
• Corporate Authors:
  Collaborative Group for Studies of Yellow Fever Vaccine
• Description:
  We evaluated the duration of neutralizing antibodies and the status of 17DD vaccine-specific T- and B-cell memory following primary and revaccination regimens for yellow fever (YF) in Brazil. We observed progressive decline of plaque-reduction neutralization test (PRNT) seropositivity and of the levels of effector memory CD4+ and CD8+ T cells, as well as interferon-γ+CD8+ T cells, 10 years after primary vaccination. Revaccination restored PRNT seropositivity as well as the levels of effector memory CD4+, CD8+, and interferon-γ+CD8+ T cells. Moreover, secondary or multiple vaccinations guarantee long-term persistence of PRNT positivity and cell-mediated memory 10 years after booster vaccination. These findings support the relevance of booster doses to heighten the 17DD-YF-specific immune response to guarantee the long-term persistence of memory components. Secondary or multiple vaccinations improved the correlates of protection triggered by 17DD-YF primary vaccination, indicating that booster regimens are needed to achieve efficient immunity in areas with high risk for virus transmission.
• Subjects:
  Adolescent Adult Aged Antibodies, Neutralizing Antibodies, Viral Dengue Virus Female Humans Immunity Immunity, Cellular Immunization, Secondary Immunoglobulin G Immunologic Memory Male Middle Aged Neutralization Tests Public Health Surveillance Yellow Fever Yellow Fever Vaccine Yellow Fever Virus Young Adult

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• Source:
  Emerg Infect Dis. 25(8):1511-1521
• Pubmed ID:
  31298654
• Pubmed Central ID:
  PMC6649311
• Document Type:
  Journal Article
• Place as Subject:
  Brazil
• Volume:
  25
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:d9acc1b31a3adaf8bbab8d4ab2a21035c3f40500b233cdb764cb406f954607c8
• Download URL:
  https://stacks.cdc.gov/view/cdc/80317/cdc_80317_DS1.pdf
• File Type:
  [PDF - 2.03 MB ]