Characterization of Nipah Virus from Outbreaks in Bangladesh, 2008–2010

Lo, Michael K.; Lowe, Luis; Hummel, Kimberly B.; Sazzad, Hossain M.S.; Gurley, Emily S.; Hossain, M. Jahangir; Luby, Stephen P.; Miller, David M.; Comer, James A.; Rollin, Pierre E.; Bellini, William J.; Rota, Paul A.

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Characterization of Nipah Virus from Outbreaks in Bangladesh, 2008–2010

Supporting Files Public Domain

Feb 2012
By Lo, Michael K. ; Lowe, Luis ; Hummel, Kimberly B. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Lo, Michael K. ; Lowe, Luis ; Hummel, Kimberly B. ; Sazzad, Hossain M.S. ; Gurley, Emily S. ; Hossain, M. Jahangir ; Luby, Stephen P. ; Miller, David M. ; Comer, James A. ; Rollin, Pierre E. ; Bellini, William J. ; Rota, Paul A.
Description:

Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the complete genomic sequences of identical NiV isolates from 2 patients in 2008 and partial genomic sequences of throat swab samples from 3 patients in 2010, all from Bangladesh. All sequences from patients in Bangladesh comprised a distinct genetic group. However, the detection of 3 genetically distinct sequences from patients in the districts of Faridpur and Gopalganj indicated multiple co-circulating lineages in a localized region over a short time (January-March 2010). Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences.
Subjects:

Amino Acid Sequence Amino Acid Substitution Child Conserved Sequence Disease Outbreaks Female Genetic Variation Genome, Viral Henipavirus Infections Humans Molecular Sequence Data Molecular Typing Nipah Virus Phylogeny Research Sequence Analysis, DNA Seroepidemiologic Studies Viral Proteins
Source:

Emerg Infect Dis. 18(2):248-255.
Document Type:

Journal Article
Place as Subject:

Bangladesh
Location:

Asia
Volume:

18
Issue:

2
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:6d49c5b1adcb4e643b50ca56b652a522e9ac8747cfccd4ecc16ac42774b9a36a
Download URL:

https://stacks.cdc.gov/view/cdc/7977/cdc_7977_DS1.pdf
File Type:

[PDF - 298.55 KB ]

File Language:

English

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