Characterization of Nipah Virus from Outbreaks in Bangladesh, 2008–2010

Lo, Michael K.; Lowe, Luis; Hummel, Kimberly B.; Sazzad, Hossain M.S.; Gurley, Emily S.; Hossain, M. Jahangir; Luby, Stephen P.; Miller, David M.; Comer, James A.; Rollin, Pierre E.; Bellini, William J.; Rota, Paul A.

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Characterization of Nipah Virus from Outbreaks in Bangladesh, 2008–2010

Published Date:

Feb 2012

Source:

Emerg Infect Dis. 18(2):248-255.

[PDF-298.55 KB]

Details:

Personal Authors:

Lo, Michael K. ; Lowe, Luis ; Hummel, Kimberly B. ; Sazzad, Hossain M.S. ; Gurley, Emily S. ; ... More ▼

Keywords:

[+]

Description:

Nipah virus (NiV) is a highly pathogenic paramyxovirus that causes fatal encephalitis in humans. The initial outbreak of NiV infection occurred in Malaysia and Singapore in 1998-1999; relatively small, sporadic outbreaks among humans have occurred in Bangladesh since 2001. We characterized the complete genomic sequences of identical NiV isolates from 2 patients in 2008 and partial genomic sequences of throat swab samples from 3 patients in 2010, all from Bangladesh. All sequences from patients in Bangladesh comprised a distinct genetic group. However, the detection of 3 genetically distinct sequences from patients in the districts of Faridpur and Gopalganj indicated multiple co-circulating lineages in a localized region over a short time (January-March 2010). Sequence comparisons between the open reading frames of all available NiV genes led us to propose a standardized protocol for genotyping NiV; this protcol provides a simple and accurate way to classify current and future NiV sequences.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases
CDC Public Access

Supporting Files:

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