Obesity and mortality after locoregional breast cancer diagnosis

Details

• Alternative Title:
  Breast Cancer Res Treat
• Personal Author:
  Moore, A. Holliston ; Trentham-Dietz, Amy ; Burns, Marguerite ; Gangnon, Ronald E. ; Greenberg, Caprice C. ; Vanness, David J. ; Hampton, John ; Wu, Xiao-Cheng ; Anderson, Roger T. ; Lipscomb, Joseph ; Kimmick, Gretchen G. ; Cress, Rosemary ; Wilson, J. Frank ; Sabatino, Susan A. ; Fleming, Steven T.
• Description:
  Purpose
  
  Higher mortality after a breast cancer diagnosis has been observed among women who are obese. We investigated the relationships between body mass index (BMI) and all-cause or breast cancer-specific mortality after a diagnosis of locoregional breast cancer.
  
  Methods
  
  Women diagnosed in 2004 with AJCC Stage I, II, or III breast cancer (n = 5394) were identified from a population-based National Program of Cancer Registries (NPCR) patterns of care study (POC-BP) drawing from registries in seven U.S. states. Differences in overall and breast cancer-specific mortality were investigated using Cox proportional hazards regression models adjusting for demographic and clinical covariates, including age- and stage-based subgroup analyses.
  
  Results
  
  In women 70 or older, higher BMI was associated with lower overall mortality (HR for a 5 kg/m2 difference in BMI = 0.85, 95% CI 0.75–0.95). There was no significant association between BMI and overall mortality for women under 70. BMI was not associated with breast cancer death in the full sample, but among women with Stage I disease; those in the highest BMI category had significantly higher breast cancer mortality (HR for BMI ≥ 35 kg/m2 vs. 18.5–24.9 kg/m2 = 4.74, 95% CI 1.78–12.59).
  
  Conclusions
  
  Contrary to our hypothesis, greater BMI was not associated with higher overall mortality. Among older women, BMI was inversely related to overall mortality, with a null association among younger women. Higher BMI was associated with breast cancer mortality among women with Stage I disease, but not among women with more advanced disease.
  
  
• Subjects:
  Adult Aged Aged, 80 And Over All-cause Mortality Article Body Mass Index Breast Cancer Breast Cancer Mortality Breast Neoplasms Female Humans Middle Aged Neoplasm Staging Obesity Proportional Hazards Models

  More +
• Source:
  Breast Cancer Res Treat. 172(3):647-657
• Pubmed ID:
  30159788
• Pubmed Central ID:
  PMC6613372
• Document Type:
  Journal Article
• Funding:
  U01 DP000261/DP/NCCDPHP CDC HHS/United States ; P30 CA014520/CA/NCI NIH HHS/United States ; P30 AG017266/AG/NIA NIH HHS/United States ; U01DP000261/Centers for Disease Control and Prevention/ ; P50 CA14520/National Institutes of Health/
• Volume:
  172
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e107eb65de825a54ed948f8a433eced12f373aff52541d7df21cc933ad66691a
• Download URL:
  https://stacks.cdc.gov/view/cdc/79704/cdc_79704_DS1.pdf
• File Type:
  [PDF - 127.98 KB ]