Nationwide Stepwise Emergence and Evolution of Multidrug-Resistant Campylobacter jejuni Sequence Type 5136, United Kingdom

Lopes, Bruno S.; Strachan, Norval J.C.; Ramjee, Meenakshi; Thomson, Anne; MacRae, Marion; Shaw, Sophie; Forbes, Ken J.

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Nationwide Stepwise Emergence and Evolution of Multidrug-Resistant Campylobacter jejuni Sequence Type 5136, United Kingdom

Published Date:

Jul 2019

Source:

Emerg Infect Dis. 25(7):1320-1329

Language:

English

[PDF-1.93 MB]

Details:

Personal Authors:

Lopes, Bruno S. ; Strachan, Norval J.C. ; Ramjee, Meenakshi ; Thomson, Anne ; MacRae, Marion ; ... More ▼

Keywords:

[+]

Pubmed ID:

31211671

Pubmed Central ID:

PMC6590748

Description:

We examined whole-genome-sequenced Campylobacter jejuni and C. coli from 2012-2015 isolated from birds and human stool samples in North East Scotland for the presence of antimicrobial resistance genes. We found that sequence type (ST) 5136 (clonal complex 464) was the most prevalent multidrug-resistant strain of C. jejuni exclusively associated with poultry host reservoirs and recovered from human cases of campylobacteriosis. Tetracycline resistance in ST5136 isolates was due to a tet(O/32/O) mosaic gene, ampicillin resistance was conferred by G → T transversion in the -10 promoter region of bla|, fluoroquinolone resistance was due to C257T change in gyrA, and aminoglycoside resistance was conferred by aac. Whole-genome analysis showed that the strain ST5136 evolved from ST464. The nationwide emergence of ST5136 was probably due to stepwise acquisition of antimicrobial resistance genes selected by high use of β-lactam, tetracycline, fluoroquinolone, and aminoglycoside classes of drugs in the poultry industry.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

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Supporting Files:

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