Immunopathology of Fatal Human Variegated Squirrel Bornavirus 1 Encephalitis, Germany, 2011–2013

Tappe, Dennis; Schmidt-Chanasit, Jonas; Rauch, Jessica; Allartz, Petra; Herden, Christiane

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Immunopathology of Fatal Human Variegated Squirrel Bornavirus 1 Encephalitis, Germany, 2011–2013

Supporting Files Public Domain

Jun 2019
By Tappe, Dennis ; Schmidt-Chanasit, Jonas ; Rauch, Jessica ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Tappe, Dennis ; Schmidt-Chanasit, Jonas ; Rauch, Jessica ; Allartz, Petra ; Herden, Christiane
Description:

Variegated squirrel bornavirus 1 (VSBV-1) is a zoonotic virus that causes fatal encephalitis in humans who are infected after contact with exotic squirrels. We analyzed the brain lesions and the immune responses in all 4 known human cases that showed panencephalitis. Inflammatory infiltrates in areas positive for VSBV-1 RNA and antigen consisted of CD4+ and CD8+ T cells, with perivascular B-cell accumulation. Strong microglial response and bizarre astroglial expansion were present. Areas of malacia contained neutrophils and foamy microglia and macrophages. Immunopathologic examination during infection showed cleavage of caspase 3 in brain cells adjacent to CD8+ cells and widespread p53 expression, hallmarks of apoptosis. Cerebrospinal fluid analyses over time demonstrated increasing protein concentrations and cell counts, paralleled by pathologic lactate elevations in all patients. The most severe cerebrospinal fluid and histologic changes occurred in the patient with the highest viral load, shortest duration of disease, and most medical preconditions.
Subjects:

Aged Animals Apoptosis Biomarkers Biopsy Bornaviridae Brain Encephalitis, Viral/Diagnosis Encephalitis, Viral/Epidemiology Encephalitis, Viral/History Encephalitis, Viral/Virology Female History, 21St Century Humans Immunohistochemistry Male Middle Aged Public Health Surveillance Rna, Viral Zoonoses
Source:

Emerg Infect Dis. 25(6):1058-1065
Pubmed ID:

31107210
Pubmed Central ID:

PMC6537742
Document Type:

Journal Article
Genre:

Historical Article
Place as Subject:

Germany
Volume:

25
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:209f18a78b630c55acba033974021d5ad40528f3133cb75c07b4b30dbf37c48b
Download URL:

https://stacks.cdc.gov/view/cdc/79407/cdc_79407_DS1.pdf
File Type:

[PDF - 6.90 MB ]

File Language:

English

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