Epidemiologic and Clinical Features of Lassa Fever Outbreak in Nigeria, January 1–May 6, 2018

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ilori, Elsie A. ; Furuse, Yuki ; Ipadeola, Oladipupo B. ; Dan-Nwafor, Chioma C. ; Abubakar, Anwar ; Womi-Eteng, Oboma E. ; Ogbaini-Emovon, Ephraim ; Okogbenin, Sylvanus ; Unigwe, Uche ; Ogah, Emeka ; Ayodeji, Olufemi ; Abejegah, Chukwuyem ; Liasu, Ahmed A. ; Musa, Emmanuel O. ; Woldetsadik, Solomon F. ; Lasuba, Clement L.P. ; Alemu, Wondimagegnehu ; Ihekweazu, Chikwe
• Corporate Authors:
  Nigeria Lassa Fever National Response Team
• Description:
  Lassa fever (LF) is endemic to Nigeria, where the disease causes substantial rates of illness and death. In this article, we report an analysis of the epidemiologic and clinical aspects of the LF outbreak that occurred in Nigeria during January 1-May 6, 2018. A total of 1,893 cases were reported; 423 were laboratory-confirmed cases, among which 106 deaths were recorded (case-fatality rate 25.1%). Among all confirmed cases, 37 occurred in healthcare workers. The secondary attack rate among 5,001 contacts was 0.56%. Most (80.6%) confirmed cases were reported from 3 states (Edo, Ondo, and Ebonyi). Fatal outcomes were significantly associated with being elderly; no administration of ribavirin; and the presence of a cough, hemorrhaging, and unconsciousness. The findings in this study should lead to further LF research and provide guidance to those preparing to respond to future outbreaks.
• Subjects:
  Adolescent Adult Aged Child Child, Preschool Disease Outbreaks Female Geography, Medical History, 21St Century Humans Infant Infant, Newborn Lassa Fever/Diagnosis Lassa Fever/Epidemiology Lassa Fever/History Lassa Fever/Virology Lassa Virus Male Middle Aged Mortality Odds Ratio Prevalence Public Health Surveillance Seasons Symptom Assessment Young Adult

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• Source:
  Emerg Infect Dis. 25(6):1066-1074
• Pubmed ID:
  31107222
• Pubmed Central ID:
  PMC6537738
• Document Type:
  Journal Article
• Genre:
  Historical Article
• Place as Subject:
  Nigeria
• Location:
  Africa
• Volume:
  25
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:08ecc684620cbfcbeef9a35bda6e680583e97bdd77253efc5d3c6766a6a28ccd
• Download URL:
  https://stacks.cdc.gov/view/cdc/79405/cdc_79405_DS1.pdf
• File Type:
  [PDF - 1.90 MB ]