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Narcolepsy and Influenza A(H1N1) Pandemic 2009 Vaccination in the United States
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11 11 2014
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Source: Neurology. 83(20):1823-1830
[PDF-452.99 KB]
Details:
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Alternative Title:Neurology
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Personal Author:
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Description:Objective:
To assess the occurrence of narcolepsy following influenza vaccines used in the United States that contained the influenza A(H1N1)pdm09 virus strain.
Methods:
A population-based cohort study in the Vaccine Safety Datalink with an annual population of over 8.5 million people. All persons <30 years old who received a 2009 pandemic or a 2010–2011 seasonal influenza vaccine were identified. Their medical visit history was searched for a first-ever occurrence of an ICD-9 narcolepsy diagnosis code through the end of 2011. Chart review was done to confirm the diagnosis and determine the date of symptom onset. Cases were patients who met the International Classification of Sleep Disorders, 2nd edition narcolepsy diagnostic criteria. We compared the observed number of cases following vaccination to the number expected to occur by chance alone.
Results:
The number vaccinated with 2009 pandemic vaccine was 650,995 and with 2010–2011 seasonal vaccine was 870,530. Among these patients, 70 had a first-ever narcolepsy diagnosis code following vaccination, of which sixteen had a chart-confirmed incident diagnosis of narcolepsy. None had their symptom onset during the 180 days following receipt of a 2009 pandemic vaccine compared to 6.52 expected, and two had onset following a 2010–2011 seasonal vaccine compared to 8.83 expected.
Conclusions:
Influenza vaccines containing the A(H1N1)pdm09 virus strain used in the United States were not associated with an increased risk of narcolepsy. Vaccination with the influenza A(H1N1)pdm09 vaccine viral antigens does not appear to be sufficient by itself to increase the incidence of narcolepsy in a population.
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Pubmed ID:25320099
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Pubmed Central ID:PMC6563919
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Volume:83
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Issue:20
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