Meeting report narcolepsy and pandemic influenza vaccination: What we know and what we need to know before the next pandemic? A report from the 2nd IABS meeting

Edwards, Kathryn; Hanquet, Germaine; Black, Steve; Mignot, Emmanuel; Jankosky, Christopher; Shimabukuro, Tom; Miller, Elizabeth; Nohynek, Hanna; Neels, Pieter

doi:10.1016/j.biologicals.2019.05.005

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Meeting report narcolepsy and pandemic influenza vaccination: What we know and what we need to know before the next pandemic? A report from the 2nd IABS meeting

Published Date:

May 23 2019

Source:

Biologicals. 60:1-7

Language:

English

Public Access Version Available on: July 01, 2020

Please check back on the date listed above.

Details:

Personal Authors:

Edwards, Kathryn ; Hanquet, Germaine ; Black, Steve ; Mignot, Emmanuel ; Jankosky, Christopher ; ... More ▼

Keywords:

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Pubmed ID:

31130313

Pubmed Central ID:

PMC6668612

Description:

A group of scientific and public health experts and key stakeholders convened to discuss the state of knowledge on the relationship between adjuvanted monovalent inactivated 2009 influenza A H1N1 vaccines used during the 2009 influenza pandemic and narcolepsy. There was consensus that an increased risk of narcolepsy was consistently observed after Pandemrix (AS03-adjuvanted) vaccine, but similar associations following Arepanrix (AS03-adjuvanted) or Focetria (MF59-adjuvanted) vaccines were not observed. Whether the differences are due to vaccine composition or other factors such as the timing of large-scale vaccination programs relative to H1N1pdm09 wild-type virus circulation in different geographic regions is not clear. The limitations of retrospective observational methodologies could also be contributing to some of the differences across studies. More basic and epidemiologic research is needed to further elucidate the association between adjuvanted influenza vaccine and narcolepsy and its mechanism and to inform planning and preparation for vaccination programs in advance of the next influenza pandemic.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Main Document Checksum:

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Supporting Files:

No Additional Files

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