Meeting report narcolepsy and pandemic influenza vaccination: What we know and what we need to know before the next pandemic? A report from the 2nd IABS meeting

Edwards, Kathryn; Hanquet, Germaine; Black, Steve; Mignot, Emmanuel; Jankosky, Christopher; Shimabukuro, Tom; Miller, Elizabeth; Nohynek, Hanna; Neels, Pieter

doi:10.1016/j.biologicals.2019.05.005

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Meeting report narcolepsy and pandemic influenza vaccination: What we know and what we need to know before the next pandemic? A report from the 2nd IABS meeting

7 2019
By Edwards, Kathryn ; Hanquet, Germaine ; Black, Steve ; ...
http://dx.doi.org/10.1016/j.biologicals.2019.05.005
Source: Biologicals. 60:1-7

[PDF-333.71 KB]

English

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Details:

Alternative Title:

Biologicals
Personal Author:

Edwards, Kathryn ; Hanquet, Germaine ; Black, Steve ; Mignot, Emmanuel ; Jankosky, Christopher ; ... More +

Edwards, Kathryn ; Hanquet, Germaine ; Black, Steve ; Mignot, Emmanuel ; Jankosky, Christopher ; Shimabukuro, Tom ; Miller, Elizabeth ; Nohynek, Hanna ; Neels, Pieter Less -
Description:

A group of scientific and public health experts and key stakeholders convened to discuss the state of knowledge on the relationship between adjuvanted monovalent inactivated 2009 influenza A H1N1 vaccines used during the 2009 influenza pandemic and narcolepsy. There was consensus that an increased risk of narcolepsy was consistently observed after Pandemrix (AS03-adjuvanted) vaccine, but similar associations following Arepanrix (AS03-adjuvanted) or Focetria (MF59-adjuvanted) vaccines were not observed. Whether the differences are due to vaccine composition or other factors such as the timing of large-scale vaccination programs relative to H1N1pdm09 wild-type virus circulation in different geographic regions is not clear. The limitations of retrospective observational methodologies could also be contributing to some of the differences across studies. More basic and epidemiologic research is needed to further elucidate the association between adjuvanted influenza vaccine and narcolepsy and its mechanism and to inform planning and preparation for vaccination programs in advance of the next influenza pandemic.
Subjects:

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Biological Science Disciplines Congresses As Topic Female Humans Influenza, Human Influenza A Virus, H1N1 Subtype Influenza Vaccines Male Narcolepsy Pandemics Societies, Scientific Vaccination
Keywords:

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Adjuvants Antigen System 03 (AS03) H1N1pdm09 Influenza Vaccines Pandemic Influenza Pandemrix Vaccine
Source:

Biologicals. 60:1-7
Pubmed ID:

31130313
Pubmed Central ID:

PMC6668612
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHSUnited States/
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:00899b37cda0364fe03c88ce19b724b3ecfc89ea12a7ce091d58b66edd7bb214
Download URL:

https://stacks.cdc.gov/view/cdc/80373/cdc_80373_DS1.pdf
File Type:

nihms-1034865.nxml

xml

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