Details:

Alternative Title:
Biologicals
Personal Author:
Edwards, Kathryn ; Hanquet, Germaine ; Black, Steve ; Mignot, Emmanuel ; Jankosky, Christopher ; ... More +
Edwards, Kathryn ; Hanquet, Germaine ; Black, Steve ; Mignot, Emmanuel ; Jankosky, Christopher ; Shimabukuro, Tom ; Miller, Elizabeth ; Nohynek, Hanna ; Neels, Pieter ; Less -
Description:
A group of scientific and public health experts and key stakeholders convened to discuss the state of knowledge on the relationship between adjuvanted monovalent inactivated 2009 influenza A H1N1 vaccines used during the 2009 influenza pandemic and narcolepsy. There was consensus that an increased risk of narcolepsy was consistently observed after Pandemrix (AS03-adjuvanted) vaccine, but similar associations following Arepanrix (AS03-adjuvanted) or Focetria (MF59-adjuvanted) vaccines were not observed. Whether the differences are due to vaccine composition or other factors such as the timing of large-scale vaccination programs relative to H1N1pdm09 wild-type virus circulation in different geographic regions is not clear. The limitations of retrospective observational methodologies could also be contributing to some of the differences across studies. More basic and epidemiologic research is needed to further elucidate the association between adjuvanted influenza vaccine and narcolepsy and its mechanism and to inform planning and preparation for vaccination programs in advance of the next influenza pandemic.
Subject:
[+]
Adjuvants
Antigen System 03 (AS03)
Article
Biological Science Disciplines
Congresses As Topic
Female
H1N1pdm09 Influenza Vaccines
Humans
Influenza, Human
Influenza A Virus, H1N1 Subtype
Influenza Vaccines
Male
Narcolepsy
Pandemic Influenza
Pandemics
Pandemrix Vaccine
Societies, Scientific
Vaccination

Source:
Biologicals. 60:1-7
Pubmed ID:
31130313
Pubmed Central ID:
PMC6668612
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:00899b37cda0364fe03c88ce19b724b3ecfc89ea12a7ce091d58b66edd7bb214
File Type:

Supporting Files

• nihms-1034865.nxml

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