Serologic Prevalence of Ebola Virus in Equatorial Africa

Steffen, Imke; Lu, Kai; Yamamoto, Lauren K.; Hoff, Nicole A.; Mulembakani, Prime; Wemakoy, Emile O.; Muyembe-Tamfum, Jean-Jacques; Ndembi, Nicaise; Brennan, Catherine A.; Hackett, John; Stramer, Susan L.; Switzer, William M.; Saragosti, Sentob; Mbensa, Guy O.; Laperche, Syria; Rimoin, Anne W.; Simmons, Graham

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Serologic Prevalence of Ebola Virus in Equatorial Africa

Supporting Files

May 2019
By Steffen, Imke ; Lu, Kai ; Yamamoto, Lauren K. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Steffen, Imke ; Lu, Kai ; Yamamoto, Lauren K. ; Hoff, Nicole A. ; Mulembakani, Prime ; Wemakoy, Emile O. ; Muyembe-Tamfum, Jean-Jacques ; Ndembi, Nicaise ; Brennan, Catherine A. ; Hackett, John ; Stramer, Susan L. ; Switzer, William M. ; Saragosti, Sentob ; Mbensa, Guy O. ; Laperche, Syria ; Rimoin, Anne W. ; Simmons, Graham
Description:

We conducted a serologic survey of 2,430 serum samples collected during 1997-2012 for various studies to determine the prevalence of the hemorrhagic fever virus Ebola virus (EBOV) in equatorial Africa. We screened serum samples for neutralizing antibodies by using a pseudotype microneutralization assay and a newly developed luciferase immunoprecipitation system assay. Specimens seroreactive for EBOV were confirmed by using an ELISA. Our results suggest a serologic prevalence of 2%-3.5% in the Republic of the Congo and the Democratic Republic of the Congo, which have reported outbreaks of infection with EBOV. In addition we detected a seroprevalence of 1.3% in southern Cameroon, which indicated a low risk for exposure in this region.
Subjects:

Antibodies, Viral Ebolavirus Enzyme-Linked Immunosorbent Assay Hek293 Cells Hemorrhagic Fever, Ebola Humans Immunoprecipitation Nucleoproteins Seroepidemiologic Studies Viral Core Proteins Viral Envelope Proteins
Source:

Emerg Infect Dis. 25(5):911-918
Pubmed ID:

31002071
Pubmed Central ID:

PMC6478206
Document Type:

Journal Article
Funding:

R21 AI107420/AI/NIAID NIH HHS/United States
Place as Subject:

Africa, Central ; Republic of the Congo ; Democratic Republic of the Congo ; Cameroon ; Uganda ; Ghana
Volume:

25
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:4633257e0b4d3b68a8c1917b60b9116f3d865367be05d799e8f8bdf585558ab3
Download URL:

https://stacks.cdc.gov/view/cdc/79338/cdc_79338_DS1.pdf
File Type:

[PDF - 1.24 MB ]

File Language:

English

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