Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed

Niederwerder, Megan C.; Stoian, Ana M.M.; Rowland, Raymond R.R.; Dritz, Steve S.; Petrovan, Vlad; Constance, Laura A.; Gebhardt, Jordan T.; Olcha, Matthew; Jones, Cassandra K.; Woodworth, Jason C.; Fang, Ying; Liang, Jia; Hefley, Trevor J.

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Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed

Supporting Files Public Domain

May 17 2019
By Niederwerder, Megan C. ; Stoian, Ana M.M. ; Rowland, Raymond R.R. ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Niederwerder, Megan C. ; Stoian, Ana M.M. ; Rowland, Raymond R.R. ; Dritz, Steve S. ; Petrovan, Vlad ; Constance, Laura A. ; Gebhardt, Jordan T. ; Olcha, Matthew ; Jones, Cassandra K. ; Woodworth, Jason C. ; Fang, Ying ; Liang, Jia ; Hefley, Trevor J.
Description:

African swine fever virus (ASFV) is a contagious, rapidly spreading, transboundary animal disease and a major threat to pork production globally. Although plant-based feed has been identified as a potential route for virus introduction onto swine farms, little is known about the risks for ASFV transmission in feed. We aimed to determine the minimum and median infectious doses of the Georgia 2007 strain of ASFV through oral exposure during natural drinking and feeding behaviors. The minimum infectious dose of ASFV in liquid was 10| 50% tissue culture infectious dose (TCID|), compared with 10| TCID| in feed. The median infectious dose was 10| TCID| for liquid and 10| TCID| for feed. Our findings demonstrate that ASFV Georgia 2007 can easily be transmitted orally, although higher doses are required for infection in plant-based feed. These data provide important information that can be incorporated into risk models for ASFV transmission.
Subjects:

African Swine Fever/epidemiology African Swine Fever/transmission African Swine Fever/virology African Swine Fever Virus/genetics African Swine Fever Virus/pathogenicity Animal Feed/virology Animals Food Microbiology Swine Virulence
Source:

Emerg Infect Dis. 25(5):891-897
Pubmed ID:

30761988
Pubmed Central ID:

PMC6478231
Document Type:

Journal Article
Place as Subject:

Georgia
Volume:

25
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:537320ee41c944b98e9ec045291b2f1128187da9dbf58fd43854f36a47f74e70
Download URL:

https://stacks.cdc.gov/view/cdc/79301/cdc_79301_DS1.pdf
File Type:

[PDF - 1.10 MB ]

File Language:

English

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