Recurrent Cholera Outbreaks, Democratic Republic of the Congo, 2008–2017

Ingelbeen, Brecht; Hendrickx, David; Miwanda, Berthe; van der Sande, Marianne A.B.; Mossoko, Mathias; Vochten, Hilde; Riems, Bram; Nyakio, Jean-Paul; Vanlerberghe, Veerle; Lunguya, Octavie; Jacobs, Jan; Boelaert, Marleen; Kebela, Benoît Ilunga; Bompangue, Didier; Muyembe, Jean-Jacques

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Recurrent Cholera Outbreaks, Democratic Republic of the Congo, 2008–2017

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May 2019
By Ingelbeen, Brecht ; Hendrickx, David ; Miwanda, Berthe ; ...

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Alternative Title:

Emerg Infect Dis
Personal Author:

Ingelbeen, Brecht ; Hendrickx, David ; Miwanda, Berthe ; van der Sande, Marianne A.B. ; Mossoko, Mathias ; Vochten, Hilde ; Riems, Bram ; Nyakio, Jean-Paul ; Vanlerberghe, Veerle ; Lunguya, Octavie ; Jacobs, Jan ; Boelaert, Marleen ; Kebela, Benoît Ilunga ; Bompangue, Didier ; Muyembe, Jean-Jacques
Description:

In 2017, the exacerbation of an ongoing countrywide cholera outbreak in the Democratic Republic of the Congo resulted in >53,000 reported cases and 1,145 deaths. To guide control measures, we analyzed the characteristics of cholera epidemiology in DRC on the basis of surveillance and cholera treatment center data for 2008-2017. The 2017 nationwide outbreak resulted from 3 distinct mechanisms: considerable increases in the number of cases in cholera-endemic areas, so-called hot spots, around the Great Lakes in eastern DRC; recurrent outbreaks progressing downstream along the Congo River; and spread along Congo River branches to areas that had been cholera-free for more than a decade. Case-fatality rates were higher in nonendemic areas and in the early phases of the outbreaks, possibly reflecting low levels of immunity and less appropriate prevention and treatment. Targeted use of oral cholera vaccine, soon after initial cases are diagnosed, could contribute to lower case-fatality rates.
Subjects:

Bacteria Cholera Disease Outbreaks Enteric Infections Epidemic History Epidemiology Recurrent Cholera Outbreaks, Democratic Republic Of The Congo, 2008-2017 Research Vibrio Cholerae
Source:

Emerg Infect Dis. 25(5):856-864
Pubmed ID:

31002075
Pubmed Central ID:

PMC6478228
Document Type:

Journal Article
Place as Subject:

Democratic Republic of the Congo
Location:

Africa
Volume:

25
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:95660f4276f10dc57da6412b431fc1c2507fb2953cc749cab1b38ea14fad85c2
Download URL:

https://stacks.cdc.gov/view/cdc/79299/cdc_79299_DS1.pdf
File Type:

[PDF - 8.14 MB ]

File Language:

English

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