Multidrug-resistant Tuberculosis Management in Resource-limited Settings

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nathanson, Eva ; Lambregts-van Weezenbeek, Catharina ; Rich, Michael L. ; Gupta, Rajesh ; Bayona, Jaime ; Blöndal, Kai ; Caminero, José A. ; Cegielski, J. Peter ; Danilovits, Manfred ; Espinal, Marcos A. ; Hollo, Vahur ; Jaramillo, Ernesto ; Leimane, Vaira ; Mitnick, Carole D. ; Mukherjee, Joia S. ; Nunn, Paul ; Pasechnikov, Alexander ; Tupasi, Thelma ; Wells, Charles ; Raviglione, Mario C.
• Description:
  Evidence of successful management of multidrug-resistant tuberculosis (MDRTB) is mainly generated from referral hospitals in high-income countries. We evaluate the management of MDRTB in 5 resource-limited countries: Estonia, Latvia, Peru, the Philippines, and the Russian Federation. All projects were approved by the Green Light Committee for access to quality-assured second-line drugs provided at reduced price for MDRTB management. Of 1047 MDRTB patients evaluated, 119 (11%) were new, and 928 (89%) had received treatment previously. More than 50% of previously treated patients had received both first- and second-line drugs, and 65% of all patients had infections that were resistant to both first- and second-line drugs. Treatment was successful in 70% of all patients, but success rate was higher among new (77%) than among previously treated patients (69%). In resource-limited settings, treatment of MDRTB provided through, or in collaboration with, national TB programs can yield results similar to those from wealthier settings.
• Subjects:
  Communicable Disease Control Developing Countries Drug Administration Schedule Government Programs Humans Program Evaluation Treatment Outcome Tuberculosis, Multidrug-Resistant
• Source:
  Emerg Infect Dis. 12(9):1389-1397.
• Document Type:
  Journal Article
• Place as Subject:
  Estonia ; Latvia ; Peru ; Philippines ; Russia
• Volume:
  12
• Issue:
  9
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:95f47a6dd53e6a3c9e77bec383eb5992903154ffd6f62971f86d566e2d8246bc
• Download URL:
  https://stacks.cdc.gov/view/cdc/7919/cdc_7919_DS1.pdf
• File Type:
  [PDF - 327.05 KB ]