Multidrug-resistant Tuberculosis Management in Resource-limited Settings

Nathanson, Eva; Lambregts-van Weezenbeek, Catharina; Rich, Michael L.; Gupta, Rajesh; Bayona, Jaime; Blöndal, Kai; Caminero, José A.; Cegielski, J. Peter; Danilovits, Manfred; Espinal, Marcos A.; Hollo, Vahur; Jaramillo, Ernesto; Leimane, Vaira; Mitnick, Carole D.; Mukherjee, Joia S.; Nunn, Paul; Pasechnikov, Alexander; Tupasi, Thelma; Wells, Charles; Raviglione, Mario C.

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Multidrug-resistant Tuberculosis Management in Resource-limited Settings

Sep 2006
By Nathanson, Eva ; Lambregts-van Weezenbeek, Catharina ; Rich, Michael L. ; ...
Source: Emerg Infect Dis. 12(9):1389-1397.

[PDF-327.05 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Nathanson, Eva ; Lambregts-van Weezenbeek, Catharina ; Rich, Michael L. ; Gupta, Rajesh ; Bayona, Jaime ; ... More +

Nathanson, Eva ; Lambregts-van Weezenbeek, Catharina ; Rich, Michael L. ; Gupta, Rajesh ; Bayona, Jaime ; Blöndal, Kai ; Caminero, José A. ; Cegielski, J. Peter ; Danilovits, Manfred ; Espinal, Marcos A. ; Hollo, Vahur ; Jaramillo, Ernesto ; Leimane, Vaira ; Mitnick, Carole D. ; Mukherjee, Joia S. ; Nunn, Paul ; Pasechnikov, Alexander ; Tupasi, Thelma ; Wells, Charles ; Raviglione, Mario C. Less -
Description:

Evidence of successful management of multidrug-resistant tuberculosis (MDRTB) is mainly generated from referral hospitals in high-income countries. We evaluate the management of MDRTB in 5 resource-limited countries: Estonia, Latvia, Peru, the Philippines, and the Russian Federation. All projects were approved by the Green Light Committee for access to quality-assured second-line drugs provided at reduced price for MDRTB management. Of 1047 MDRTB patients evaluated, 119 (11%) were new, and 928 (89%) had received treatment previously. More than 50% of previously treated patients had received both first- and second-line drugs, and 65% of all patients had infections that were resistant to both first- and second-line drugs. Treatment was successful in 70% of all patients, but success rate was higher among new (77%) than among previously treated patients (69%). In resource-limited settings, treatment of MDRTB provided through, or in collaboration with, national TB programs can yield results similar to those from wealthier settings.
Subjects:

[+]

Communicable Disease Control Developing Countries Drug Administration Schedule Government Programs Humans Program Evaluation Treatment Outcome Tuberculosis, Multidrug-Resistant
Source:

Emerg Infect Dis. 12(9):1389-1397.
Document Type:

Journal Article
Place as Subject:

Estonia ; Latvia ; Peru ; Philippines ; Russia

Estonia ; Latvia ; Peru ; Philippines ; Russia Less -
Volume:

12
Issue:

9
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:95f47a6dd53e6a3c9e77bec383eb5992903154ffd6f62971f86d566e2d8246bc
Download URL:

https://stacks.cdc.gov/view/cdc/7919/cdc_7919_DS1.pdf
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