Invasive Enterobacter sakazakii Disease in Infants

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bowen, Anna B. ; Braden, Christopher R.
• Description:
  Enterobacter sakazakii kills 40%-80% of infected infants and has been associated with powdered formula. We analyzed 46 cases of invasive infant E. sakazakii infection to define risk factors and guide prevention and treatment. Twelve infants had bacteremia, 33 had meningitis, and 1 had a urinary tract infection. Compared with infants with isolated bacteremia, infants with meningitis had greater birthweight (2,454 g vs. 850 g, p = 0.002) and gestational age (37 weeks vs. 27.8 weeks, p = 0.02), and infection developed at a younger age (6 days vs. 35 days, p<0.001). Among meningitis patients, 11 (33%) had seizures, 7 (21%) had brain abscess, and 14 (42%) died. Twenty-four (92%) of 26 infants with feeding patterns specified were fed powdered formula. Formula samples associated with 15 (68%) of 22 cases yielded E. sakazakii; in 13 cases, clinical and formula strains were indistinguishable. Further clarification of clinical risk factors and improved powdered formula safety is needed.
• Subjects:
  Cronobacter Sakazakii Enterobacteriaceae Infections Female Food Microbiology Humans Infant Infant, Low Birth Weight Infant, Newborn Infant, Premature Infant, Premature, Diseases Infant Formula Male Meningitis, Bacterial Risk Factors Synopsis

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• Source:
  Emerg Infect Dis. 12(8):1185-1189.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e4cc1b0e467e82ea2fb86763a423cca65ac88a59165d110744080902e699d24a
• Download URL:
  https://stacks.cdc.gov/view/cdc/7913/cdc_7913_DS1.pdf
• File Type:
  [PDF - 86.79 KB ]