Details:

Alternative Title:
Epidemiol Infect
Publisher's site:
http://dx.doi.org/10.1017/S0950268813000800
Personal Author:
CARDEMIL, C. V. ; RATHEE, M. ; GARY, H. ; WANNEMUEHLER, K. ; ANAND, A. ; ... More +
CARDEMIL, C. V. ; RATHEE, M. ; GARY, H. ; WANNEMUEHLER, K. ; ANAND, A. ; MACH, O. ; BAHL, S. ; WASSILAK, S. ; CHU, S.Y. ; KHERA, A. ; JAFARI, H.S. ; PALLANSCH, M.A. Less -
Description:
Since 2004, efforts to improve poliovirus detection have significantly increased the volume of specimen testing from acute flaccid paralysis (AFP) patients in India. One option to decrease collection and testing burden would be collecting only a single stool specimen instead of two. We investigated stool specimen sensitivity for poliovirus detection in India to estimate the contribution of the second specimen. We reviewed poliovirus isolation data for 303984 children aged <15 years with AFP during 2000-2010. Using maximum-likelihood estimation, we determined specimen sensitivity of each stool specimen, combined sensitivity of both specimens, and sensitivity added by the second specimen. Of 5184 AFP patients with poliovirus isolates, 382 (7.4%) were identified only by the second specimen. Sensitivity was 91.4% for the first specimen and 84.5% for the second specimen; the second specimen added 7.3% sensitivity, giving a combined sensitivity of 98.7%. Combined sensitivity declined, and added sensitivity increased, as the time from paralysis onset to stool collection increased (P = 0.032). The sensitivity added by the second specimen is important to detect the last chains of poliovirus transmission and to achieve certification of polio eradication. For sensitive surveillance, two stool specimens should continue to be collected from each AFP patient in India.
Subjects:
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Adolescent Article Child Child, Preschool Feces Female Humans Infant Infant, Newborn Male Poliomyelitis Poliovirus Public Health Surveillance Sensitivity And Specificity Virology
Source:
Epidemiol Infect. 142(1):163-171
Pubmed ID:
23594458
Pubmed Central ID:
PMC6546098
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
India
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:653d00060487e201d5a093dc4e5267b7be538fd454377be2af8f0a7201b404df
Download URL:
https://stacks.cdc.gov/view/cdc/79092/cdc_79092_DS1.pdf
File Type:

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