Severe Community-acquired Pneumonia Due to Staphylococcus aureus, 2003–04 Influenza Season

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• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hageman, Jeffrey C. ; Uyeki, Timothy M. ; Francis, John S. ; Jernigan, Daniel B. ; Wheeler, J. Gary ; Bridges, Carolyn B. ; Barenkamp, Stephen J. ; Sievert, Dawn M. ; Srinivasan, Arjun ; Doherty, Meg C. ; McDougal, Linda K. ; Killgore, George E. ; Lopatin, Uri A. ; Coffman, Rebecca ; MacDonald, J. Kathryn ; McAllister, Sigrid K. ; Fosheim, Gregory E. ; Patel, Jean B. ; McDonald, L. Clifford ; Hageman, Jeffrey C. ; Uyeki, Timothy M. ; Francis, John S. ; Jernigan, Daniel B. ; Wheeler, J. Gary ; Bridges, Carolyn B. ; Barenkamp, Stephen J. ; Sievert, Dawn M. ; Srinivasan, Arjun ; Doherty, Meg C. ; McDougal, Linda K. ; Killgore, George E. ; Lopatin, Uri A. ; Coffman, Rebecca ; MacDonald, J. Kathryn ; McAllister, Sigrid K. ; Fosheim, Gregory E. ; Patel, Jean B. ; McDonald, L. Clifford
• Description:
  During the 2003-04 influenza season, 17 cases of Staphylococcus aureus community-acquired pneumonia (CAP) were reported from 9 states; 15 (88%) were associated with methicillin-resistant S. aureus (MRSA). The median age of patients was 21 years; 5 (29%) had underlying diseases, and 4 (24%) had risk factors for MRSA. Twelve (71%) had laboratory evidence of influenza virus infection. All but 1 patient, who died on arrival, were hospitalized. Death occurred in 5 (4 with MRSA). S. aureus isolates were available from 13 (76%) patients (11 MRSA). Toxin genes were detected in all isolates; 11 (85%) had only genes for Panton-Valentine leukocidin. All isolates had community-associated pulsed-field gel electrophoresis patterns; all MRSA isolates had the staphylococcal cassette chromosome mec type IVa. In communities with a high prevalence of MRSA, empiric therapy of severe CAP during periods of high influenza activity should include consideration for MRSA.
• Subjects:
  Adolescent Adult Child Child, Preschool Community-Acquired Infections DNA, Bacterial Electrophoresis, Gel, Pulsed-Field Female Genotype Humans Infant Influenza, Human Male Methicillin Resistance Microbial Sensitivity Tests Middle Aged Orthomyxoviridae Pneumonia, Bacterial Research Staphylococcal Infections Staphylococcus Aureus

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• Source:
  Emerg Infect Dis. 12(6):894-899. ; Emerg Infect Dis. 12(6):894-899.
• Document Type:
  Journal Article
• Volume:
  12
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:5d9909986201dcfba3a820ab90c2e133540f9bc2d4d07e2fbda72c3355eb712b
• Download URL:
  https://stacks.cdc.gov/view/cdc/7905/cdc_7905_DS1.pdf
• File Type:
  [PDF - 278.00 KB ]