Sociodemographic, health behavioral, and clinical risk factors for anotia/microtia in a population-based case-control study

Details

• Journal Article:
  Int J Pediatr Otorhinolaryngol
• Personal Author:
  Ryan, Marisa A. ; Olshan, Andrew F. ; Canfield, Mark A. ; Hoyt, Adrienne T. ; Scheuerle, Angela E. ; Carmichael, Suzan L. ; Shaw, Gary M. ; Werler, Martha M. ; Fisher, Sarah C. ; Desrosiers, Tania A.
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  Objective: ; Anotia and microtia are congenital malformations of the external ear with few known risk factors. We conducted a comprehensive assessment of a wide range of potential risk factors using data from the National Birth Defects Prevention Study (NBDPS), a population-based case-control study of non-chromosomal structural birth defects in the United States. ; Methods: ; Mothers of 699 infants with anotia or microtia (cases) and 11,797 non-malformed infants (controls) delivered between 1997 and 2011 were interviewed to obtain information about sociodemographic, health behavioral, and clinical characteristics. Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) were estimated with logistic regression. ; Results: ; Infants with anotia/microtia were more likely to be male (aOR, 1.29; 95% CI, 1.10–1.50) and from a multifetal pregnancy (aOR, 1.68; 95% CI, 1.16–2.42). Cases were also more likely to have parents of Hispanic ethnicity (maternal aOR, 3.19; 95% CI, 2.61–3.91; paternal aOR, 2.11; 95% CI, 1.54–2.88), and parents born outside the United States (maternal aOR, 1.29; 95% CI, 1.06–1.57; paternal aOR, 1.92; 95% CI, 1.53–2.41). Maternal health conditions associated with increased odds of anotia/microtia included obesity (aOR, 1.31; 95% CI, 1.06–1.61) and pre-pregnancy diabetes (type I aOR, 9.89; 95% CI, 5.46–17.92; type II aOR, 4.70; 95% CI, 2.56–8.63). Reduced odds were observed for black mothers (aOR, 0.57; 95% CI, 0.38–0.85) and mothers reporting daily intake of folic acid-containing supplements (aOR, 0.59; 95% CI, 0.46–0.76). ; Conclusion: ; We identified several risk factors for anotia/microtia, some which have been previously reported (e.g., diabetes) and others which we examined for perhaps the first time (e.g., binge drinking) that warrant further investigation. Our findings point to some potentially modifiable risk factors and provide further leads toward understanding the etiology of anotia/microtia.
• Subjects:
  • Adult
  • Black or African American
  • Case-Control Studies
  • Congenital Microtia
  • Diabetes Mellitus
  • Dietary Supplements
  • Ear, External
  • Fathers
  • Female
  • Folic Acid
  More +
• Keywords:
  • birth defect
  • congenital malformation
  • anotia
  • microtia
  • ear
• Source:
  Int J Pediatr Otorhinolaryngol. 122:18-26
• DOI:
  http://dx.doi.org/10.1016/j.ijporl.2019.03.026
• Pubmed ID:
  30928866
• Pubmed Central ID:
  PMC6536360
• Document Type:
  Text ; Journal Article
• Funding:
  T32 DC013018/DC/NIDCD NIH HHSUnited States/ ; U01 DD001231/DD/NCBDD CDC HHSUnited States/ ; U01 DD001224/DD/NCBDD CDC HHSUnited States/ ; U01 DD000488/DD/NCBDD CDC HHSUnited States/ ; U01DD001036/ACL/ACL HHSUnited States/ ; U01 DD001226/DD/NCBDD CDC HHSUnited States/
• Genre:
  Journal Article
• Volume:
  122
• Download URL:
  https://stacks.cdc.gov/view/cdc/78740/cdc_78740_DS1.pdf
• File Type:
  [PDF - 133.23 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:a9ae96b9ac1ea8675ba9d131ecd4b3ca8f827bd789133061771614a589609dc3e52f2cb635b5e565d49fffa7342571653c1f4203b6fc9b0be4e7c3c00698605a