QRAD (Quantal Risk Assessment Database): a database for exploring patterns in quantal dose-response data in risk assessment and its application to develop priors for Bayesian dose-response analysis

Details

• Alternative Title:
  Risk Anal
• Personal Author:
  Wheeler, Matthew W. ; Piegorsch, Walter W. ; Bailer, A. John
• Description:
  Quantitative risk assessments for physical, chemical, biological, occupational, or environmental agents rely on scientific studies to support their conclusions. These studies often include relatively few observations, and, as a result, models used to characterize the risk may include large amounts of uncertainty. The motivation, development, and assessment of new methods for risk assessment is facilitated by the availability of a set of experimental studies that span a range of dose-response patterns that are observed in practice. We describe construction of such a historical database focusing on quantal data in chemical risk assessment, and we employ this database to develop priors in Bayesian analyses. The database is assembled from a variety of existing toxicological data sources and contains 733 separate quantal dose-response data sets. As an illustration of the database's use, prior distributions for individual model parameters in Bayesian dose-response analysis are constructed. Results indicate that including prior information based on curated historical data in quantitative risk assessments may help stabilize eventual point estimates, producing dose-response functions that are more stable and precisely estimated. These in turn produce potency estimates that share the same benefit. We are confident that quantitative risk analysts will find many other applications and issues to explore using this database.
• Subjects:
  Alpha-Chlorohydrin Animals Bayes Theorem Databases, Factual Dose-Response Relationship, Drug Humans Male Probability Programming Languages Public Health Rats Rats, Sprague-Dawley Risk Assessment Software Uncertainty

  More +
• Keywords:
  Bayesian Prior Elicitation BMDS Software Carcinogenicity Data Mining Knowledgebase Quantal Dose-response Data R Software Statistical Methods Toxicology
• Source:
  Risk Anal. 39(3):616-629
• Pubmed ID:
  30368842
• Pubmed Central ID:
  PMC6408269
• Document Type:
  Journal Article
• Funding:
  P30 ES006694/ES/NIEHS NIH HHSUnited States/ ; R03 ES027394/ES/NIEHS NIH HHSUnited States/ ; CC999999/Intramural CDC HHSUnited States/ ; #R03-ES027394/U.S. National Institutes of HealthInternational/ ; #CCF-1740858/National Science FoundationInternational/
• Volume:
  39
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:07de1d623961ecceff9d8718a54cb2d81efd73e50edac62b2ce609c9101d6983
• Download URL:
  https://stacks.cdc.gov/view/cdc/78516/cdc_78516_DS1.pdf
• File Type:
  [PDF - 568.99 KB ]