Influenza-associated Hospitalization in Children Younger Than 5 Years of Age in Suzhou, China, 2011–2016

Details

• Alternative Title:
  Pediatr Infect Dis J
• Personal Author:
  Yu, Jia ; Zhang, Xiyan ; Shan, Wei ; Gao, Junmei ; Hua, Jun ; Tian, Jianmei ; Ding, Yunfang ; Zhang, Jun ; Chen, Liling ; Song, Ying ; Zhou, Suizan ; Iuliano, A. Danielle ; Greene, Carolyn M. ; Zhang, Tao ; Zhao, Genming
• Description:
  Background:
  
  Studying the burden and risk factors associated with severe illness from influenza infection in young children in eastern China will contribute to future cost-effectiveness analyses of local influenza vaccine programs.
  
  Methods:
  
  We conducted prospective, severe acute respiratory infection (SARI) surveillance at Suzhou University–Affiliated Children’s Hospital to estimate influenza-associated hospitalizations in Suzhou University–Affiliated Children’s Hospital by month in children younger than 5 years of age from October 2011 to September 2016. SARI was defined as fever (measured axillary temperature ≥ 38°C) and cough or sore throat or inflamed/red pharynx in the 7 days preceding hospitalization. We combined SARI surveillance data with healthcare utilization survey data to estimate and characterize the burden of influenza-associated SARI hospitalizations in Suzhou within this age group in the 5-year period.
  
  Results:
  
  Of the 36,313 SARI cases identified, 2,297 from respiratory wards were systematically sampled; of these, 259 (11%) were influenza positive. Estimated annual influenza-associated SARI hospitalization rates per 1,000 children younger than 5 years of age ranged from 4 (95% confidence interval [CI], 2–5) in the 2012–2013 season to 16 (95% CI, 14–19) in the 2011–2012 season. The predominant viruses were A/H3N2 (59%) in 2011–12, both A/H1N1pdm09 (42%) and B (46%) in 2012–13, A/H3N2 (71%) in 2013–14, A/H3N2 (55%) in 2014–15 and both A/H1N1pdm09 (50%) and B (50%) in 2015–16. The age-specific influenza-associated SARI hospitalization rates for the 5-year period were 11 (95% CI, 8–15) per 1,000 children 0–5 months of age; 8 (95% CI, 7–10) per 1,000 children 6–23 months of age and 5 (95% CI, 4–5) per 1,000 children 24–59 months of age, respectively.
  
  Conclusions:
  
  From 2011 to 2016, influenza-associated SARI hospitalization rates in children aged younger than 5 years of age in Suzhou, China, were high, particularly among children 0–5 months of age. Higher hospitalization rates were observed in years where the predominant circulating virus was influenza A/H3N2. Immunization for children > 6 months, and maternal and caregiver immunization for those < 6 months, could reduce influenza-associated hospitalizations in young children in Suzhou.
  
  
• Subjects:
  Child, Preschool China Cost Of Illness Epidemiological Monitoring Female Hospitalization Hospitals, Pediatric Humans Infant Infant, Newborn Influenza, Human Male Prospective Studies Risk Factors

  More +
• Keywords:
  Children Hospitalization Rates Influenza
• Source:
  Pediatr Infect Dis J. 38(5):445-452
• Pubmed ID:
  30153228
• Pubmed Central ID:
  PMC6501799
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U2G GH000018/GH/CGH CDC HHSUnited States/
• Volume:
  38
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:13a096dc46bb3b74ed2070a38aac46d63f20efb42172c68dd18fa90e20308845406d70be3d69ca7a5985e1c722470305529a083959cbcaeb1ab35dfff26a6740
• Download URL:
  https://stacks.cdc.gov/view/cdc/78354/cdc_78354_DS1.pdf
• File Type:
  [PDF - 715.24 KB ]