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Intussusception-related Hospitalizations among Infants before and after Private Market Licensure of Rotavirus Vaccines in Taiwan, 2001-2013
  • Published Date:
    Oct 2017
  • Source:
    Pediatr Infect Dis J. 36(10):e252-e257
  • Language:
    English
Filetype[PDF-275.77 KB]


Details:
  • Pubmed ID:
    28640005
  • Pubmed Central ID:
    PMC6501187
  • Description:
    Introduction:

    Rotavirus is a leading cause of acute gastroenteritis among Taiwanese children. Two globally licensed rotavirus vaccines recommended for inclusion in routine immunization programs that have been available for private market use in Taiwan since 2006 have been associated with a low risk of intussusception in post-marketing studies conducted in several countries. Our objective was to examine trends and characteristics of intussusception hospitalizations in Taiwan among children aged <12 months before and after rotavirus vaccine licensure to provide updated baseline and early post-licensure data.

    Methods:

    We extracted data on intussusception-related hospitalizations among children aged <12 months during 2001–2013 from the National Health Insurance Research Database. We examined patient demographics, clinical outcome, and hospitalization trends, focusing on recommended ages for rotavirus vaccination (6–14 weeks, 15–24 weeks, and 25–34 weeks). We compared mean hospitalization rates for pre-vaccine licensure years 2001–2005 with those for post-vaccine licensure years 2007–2013 using Poisson regression analysis.

    Results:

    During 2001–2013, 1998 intussusceptions hospitalizations were recorded. The mean age of hospitalization was 33 weeks. Almost all children recovered; 3 deaths occurred. The overall intussusception hospitalization rate was 75.1 per 100,000; seasonality was not evident. Hospitalization rates were greatest in children aged ≥25 weeks and occurred more frequently in boys. Pre-vaccine and post-vaccine licensure trends in annual hospitalization rates did not significantly differ. However, mean hospitalization rates were lower during the post-vaccine licensure period for children aged <12 months (RR: 0.84, 95% CI: 0.76–0.92) with the greatest decline among children aged 25–34 weeks (RR: 0.66, 95% CI: 0.55–0.78).

    Conclusions:

    Infant intussusception in Taiwan occurs at a rate within the range of other Asian countries, is rare among children aged <3 months, has a male predominance, and does not have a clear seasonality pattern. We did not observe a post-licensure increase in intussusception hospitalization rates in children aged 6–14 weeks.

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