Details:

Alternative Title:
Vaccine
Personal Author:
Liu, Na ; Yen, Catherine ; Huang, Tao ; Cui, Pengwei ; Tate, Jacqueline E. ; ... More +
Liu, Na ; Yen, Catherine ; Huang, Tao ; Cui, Pengwei ; Tate, Jacqueline E. ; Jiang, Baoming ; Parashar, Umesh D. ; Duan, Zhao-jun Less -
Description:
Introduction:

In China, rotavirus is the leading cause of diarrhea hospitalizations among children aged <5 years. A locally manufactured rotavirus vaccine is available for private market use, but little is known about its coverage. Given the impending availability of newer rotavirus vaccines, we evaluated intussusception rates among children aged <2 years to better understand intussusception epidemiology for future vaccine safety monitoring.

Methods:

We conducted a retrospective review at 4 hospitals in Chenzhou City of Hunan Province and Kaifeng City of Henan Province. We identified intussusception cases admitted during 2009–2013 by reviewing medical records with the ICD-10 discharge code for intussusception and extracting demographic and clinical information from the electronic clinical record systems.

Results:

During 2009–2013, 1715 intussusception hospitalizations among 1,487,215 children aged <2 years occurred in both cities. The average annual intussusception hospitalization incidence was 112.9 per 100,000 children aged <2 years (181.8 per 100,000 children <1 year; 56 per 100,000 children 1 to <2 years). Intussusception incidence was low among infants aged <3 months and peaked at age 6–8 months. No clear seasonality was observed. Ultrasound was used to diagnose 95.9% of cases. Enema reduction was performed in 80% cases; 25% of cases in Chenzhou and 16% in Kaifeng required surgical intervention. No deaths were reported. The median time between symptom onset and admission was 1 day.

Conclusions:

This study provides information on intussusception incidence and epidemiology in two cities of China during 2009–2013. Monitoring intussusception rates in this population will be important in the post-rotavirus vaccine era.


Subjects:
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Article Diarrhea Female Hospitalization Humans Incidence Infant Infant, Newborn Intussusception Male Medical Records Retrospective Studies Rotavirus Infections Rotavirus Vaccines Ultrasonography
Source:
Vaccine. 36(51):7862-7867
Pubmed ID:
29439864
Pubmed Central ID:
PMC6502226
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
China
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:57ccc3c883deca1f254312d403c3c2c88ee7de901854967014cd3a5d9d882d19
Download URL:
https://stacks.cdc.gov/view/cdc/78358/cdc_78358_DS1.pdf
File Type:

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