Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Kalish, Marcia L. ; Robbins, Kenneth E. ; Pieniazek, Danuta ; Schaefer, Amanda ; Nzilambi, Nzila ; ... More +
Kalish, Marcia L. ; Robbins, Kenneth E. ; Pieniazek, Danuta ; Schaefer, Amanda ; Nzilambi, Nzila ; Quinn, Thomas C. ; St. Louis, Michael E. ; Youngpairoj, Ae S. ; Phillips, Jonathan ; Jaffe, Harold W. ; Folks, Thomas M. Less -
Description:
Central Africa was the epicenter of the HIV type 1 (HIV-1) pandemic. Understanding the early epidemic in the Democratic Republic of the Congo, formerly Zaire, could provide insight into how HIV evolved and assist vaccine design and intervention efforts. Using enzyme immunosorbent assays, we tested 3,988 serum samples collected in Kinshasa in the mid-1980s and confirmed seroreactivity by Western blot. Polymerase chain reaction of gag p17, env C2V3C3, and/or gp41; DNA sequencing; and genetic analyses were performed. Gene regions representing all the HIV-1 group M clades and unclassifiable sequences were found. From two or three short gene regions, 37% of the strains represented recombinant viruses, multiple infections, or both, which suggests that if whole genome sequences were available, most of these strains would have mosaic genomes. We propose that the HIV epidemic was well established in central Africa by the early 1980s and that some recombinant viruses most likely seeded the early global epidemic.
Subject:
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Disease Outbreaks
Global Health
HIV-1
HIV Infections
Humans
Phylogeny
Recombination, Genetic
Research
Sequence Analysis, DNA

Source:
Emerg Infect Dis. 10(7):1227-1234.
Document Type:
Journal Article
Place as Subject:
Democratic Republic of the Congo
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:f855ab771b65d27d5f4ec4d2bd3d47bb9ea0719d934594ea2421cfecd8dd2ab2
File Type:

Supporting Files

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