Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Shen, Zhuang ; Ning, Fang ; Zhou, Weigong ; He, Xiong ; Lin, Changying ; ... More +
Shen, Zhuang ; Ning, Fang ; Zhou, Weigong ; He, Xiong ; Lin, Changying ; Chin, Daniel P. ; Zhu, Zonghan ; Schuchat, Anne Less -
Description:
Superspreading events were pivotal in the global spread of severe acute respiratory syndrome (SARS). We investigated superspreading in one transmission chain early in Beijing's epidemic. Superspreading was defined as transmission of SARS to at least eight contacts. An index patient with onset of SARS 2 months after hospital admission was the source of four generations of transmission to 76 case-patients, including 12 healthcare workers and several hospital visitors. Four (5%) case circumstances met the superspreading definition. Superspreading appeared to be associated with older age (mean 56 vs. 44 years), case fatality (75% vs. 16%, p = 0.02, Fisher exact test), number of close contacts (36 vs. 0.37) and attack rate among close contacts (43% vs. 18.5%, p < 0.025). Delayed recognition of SARS in a hospitalized patient permitted transmission to patients, visitors, and healthcare workers. Older age and number of contacts merit investigation in future studies of superspreading.
Subject:
[+]
Adult
Aged
Aged, 80 And Over
Contact Tracing
Disease Outbreaks
Epidemiologic Factors
Female
Health Personnel
Humans
Infectious Disease Transmission, Patient-to-Professional
Male
Middle Aged
Research
Severe Acute Respiratory Syndrome
Time Factors

Source:
Emerg Infect Dis. 10(2):256-260.
Document Type:
Journal Article
Place as Subject:
China
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:36b113dc6f6772572733f982ee06fdfc6e5754bd58540f4d4db461012998f7cc
File Type:

Supporting Files

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