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Incidence Trends in Pathogen-specific, Central Line-associated Bloodstream Infections in US Intensive Care Units, 1990–2010
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  • Alternative Title:
    Infect Control Hosp Epidemiol
  • Description:

    To quantify historical trends in rates of central line-associated bloodstream infections (CLABSIs) in U.S. intensive care units (ICUs) caused by major pathogen groups, including Candida spp., Enterococcus spp., specified Gram-negative rods, and Staphylococcus aureus.


    Active surveillance in a cohort of participating ICUs through the U.S. Centers for Disease Control and Prevention (CDC), National Nosocomial Infections Surveillance (NNIS) system during 1990–2004 and the National Healthcare Safety Network (NHSN) during 2006–2010.



    Patients or participants

    Patients who were admitted to participating ICUs




    The CLABSI incidence density rate for S. aureus decreased annually starting in 2002 and remained lower than for other pathogen groups. Since 2006, the annual decrease for S. aureus CLABSIs in non-pediatric ICU types was −18.3% (95% CI, −20.8% to −15.8%), whereas the incidence density rate for S. aureus among pediatric ICUs did not change. The annual decrease for all ICUs combined since 2006 was −17.8% (95% CI, −19.4% to −16.1%) for Enterococcus spp., −16.4% (95% CI, −18.2% to −14.7%) for Gram-negative rods, and −13.5% (95% CI, −15.4% to −11.5%) for Candida spp.


    Patterns of ICU CLABSI incidence density rates among major pathogen groups have changed considerably during recent decades. CLABSI incidence declined steeply since 2006, except for CLABSI due to S. aureus in pediatric ICUs. There is a need to better understand CLABSIs that still do occur based on microbiological and patient characteristics. New prevention approaches may be needed in addition to central line insertion and maintenance practices.

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