Details:

Alternative Title:
PLoS One
Personal Author:
Nwana, Nwabunie; Marks, Suzanne M.; Lan, Edward; Chang, Alicia H.; Holcombe, Michael; ... More +
Nwana, Nwabunie; Marks, Suzanne M.; Lan, Edward; Chang, Alicia H.; Holcombe, Michael; Morris, Sapna Bamrah; Less -
Description:
Objectives To investigate treatment outcomes and associated characteristics of persons experiencing homelessness who received 12-weekly doses of directly observed isoniazid and rifapentine (3HP/DOT) treatment for latent TB infection (LTBI). Methods Among homeless persons treated with 3HP/DOT during July 2011 –June 2015 in 11 U.S. TB programs, we conducted descriptive analyses of observational data, and identified associations between sociodemographic factors and treatment outcomes. Qualitative interviews were conducted to understand programmatic experiences. Results Of 393 persons experiencing homelessness (median age: 50 years; range: 13–74 years), 301 (76.6%) completed treatment, 55 (14.0%) were lost to follow-up, 18 (4.6%) stopped because of an adverse event (AE), and 19 (4.8%) stopped after relocations or refusing treatment. Eighty-one (20.6%) had at least one AE. Persons aged ≥65 were more likely to discontinue treatment than persons aged 31–44 years. Programs reported difficulty in following up with persons experiencing homelessness because of relocations, mistrust, and alcohol or drug use. Conclusions This study demonstrates the feasibility of administering the 3HP/DOT LTBI regimen to persons experiencing homelessness, a high-risk population.
Subject:
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Adolescent
Adult
Aged
Antitubercular Agents
Drug Therapy, Combination
Female
Follow-Up Studies
Homeless Persons
Humans
Isoniazid
Latent Tuberculosis
Male
Middle Aged
Mycobacterium Tuberculosis
Rifampin

Source:
PLoS One. 14(3);
Pubmed ID:
30865724
Pubmed Central ID:
PMC6415837
Document Type:
Journal Article;
Place as Subject:
United States;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:edb85dda4a51c85c8d662d341e182a9426de6284ca0db2f97cbd9442bd130e85
File Type:

Supporting Files

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