Serological response to influenza vaccination among adults hospitalized with community‐acquired pneumonia

Details

• Alternative Title:
  Influenza Other Respir Viruses
• Personal Author:
  Pratt, Caroline Quinn ; Zhu, Yuwei ; Grijalva, Carlos G. ; Wunderink, Richard G. ; Mark Courtney, D. ; Waterer, Grant ; Levine, Min Z ; Jefferson, Stacie ; Self, Wesley H. ; Williams, Derek J. ; Finelli, Lynn ; Bramley, Anna M. ; Edwards, Kathryn M. ; Jain, Seema ; Anderson, Evan J.
• Description:
  Ninety-five adults enrolled in the Etiology of Pneumonia in the Community study with negative admission influenza polymerase chain reaction (PCR) tests received influenza vaccination during hospitalization. Acute and convalescent influenza serology was performed. After vaccination, seropositive (≥1:40) hemagglutination antibody titers (HAI) were achieved in 55% to influenza A(H1N1)pdm09, 58% to influenza A(H3N2), 77% to influenza B (Victoria), and 74% to influenza B (Yamagata) viruses. Sixty-six (69%) patients seroconverted (≥4-fold HAI rise) to ≥1 strain. Failure to seroconvert was associated with diabetes, bacterial detection, baseline seropositive titers for influenza B (Yamagata), and influenza vaccination in the previous season.
• Subjects:
  Short Article
• Source:
  Influenza Other Respir Viruses. 13(2):208-212
• Pubmed ID:
  30485702
• Pubmed Central ID:
  PMC6379631
• Document Type:
  Journal Article
• Funding:
  Influenza Division, National Center for Immunization and Respiratory Diseases/
• Volume:
  13
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:fa54a2ad25262e16549074d8cbf4c8003f8f954dbbc08b81b3e1cb9ed3e4a3b9
• Download URL:
  https://stacks.cdc.gov/view/cdc/77371/cdc_77371_DS1.pdf
• File Type:
  [PDF - 279.72 KB ]