Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014

Details

• Alternative Title:
  Influenza Other Respir Viruses
• Personal Author:
  McAnerney, Johanna M ; Treurnicht, Florette ; Walaza, Sibongile ; Cohen, Adam L ; Tempia, Stefano ; Mtshali, Senzo ; Buys, Amelia ; Blumberg, Lucille ; Cohen, Cheryl
• Description:
  The effectiveness of the trivalent seasonal influenza vaccine during the 2014 season in South Africa was assessed using a test-negative case-control study design including 472 cases and 362 controls. Influenza A(H3N2) was the dominant strain circulating. The overall vaccine effectiveness estimate, adjusted for age and underlying conditions, was 43·1% (95% CI: -26·8-74·5). 2014 H3N2 viruses from South Africa were mainly in sublineage 3C.3 with accumulation of amino acid changes that differentiate them from the vaccine strain in 3C.1.
• Subjects:
  Effectiveness Influenza Short Article Vaccine
• Source:
  Influenza Other Respir Viruses. 2015; 9(4):209-215.
• Pubmed ID:
  25865249
• Pubmed Central ID:
  PMC4474497
• Document Type:
  Journal Article
• Funding:
  U51/IP000155-04/IP/NCIRD CDC HHS/United States
• Volume:
  9
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0c3d3472f0cdf18fed053cd47090dce62472ddd0b18ffca433593811579f4bc9
• Download URL:
  https://stacks.cdc.gov/view/cdc/31956/cdc_31956_DS1.pdf
• File Type:
  [PDF - 302.64 KB ]