Burden and epidemiology of influenza‐ and respiratory syncytial virus‐associated severe acute respiratory illness hospitalization in Madagascar, 2011‐2016

Details

• Alternative Title:
  Influenza Other Respir Viruses
• Personal Author:
  Rabarison, Joelinotahina H. ; Tempia, Stefano ; Harimanana, Aina ; Guillebaud, Julia ; Razanajatovo, Norosoa H. ; Ratsitorahina, Maherisoa ; Heraud, Jean‐Michel
• Description:
  Background
  
  Influenza and respiratory syncytial virus (RSV) infections are responsible for substantial global morbidity and mortality in young children and elderly individuals. Estimates of the burden of influenza‐ and RSV‐associated hospitalization are limited in Africa.
  
  Methods
  
  We conducted hospital‐based surveillance for laboratory‐confirmed influenza‐ and RSV‐associated severe acute respiratory illness (SARI) among patients of any age at one hospital and a retrospective review of SARI hospitalizations in five hospitals situated in Antananarivo during 2011‐2016. We estimated age‐specific rates (per 100 000 population) of influenza‐ and RSV‐associated SARI hospitalizations for the Antananarivo region and then extrapolated these rates to the national level.
  
  Results
  
  Overall, the mean annual national number of influenza‐associated SARI hospitalizations for all age groups was 6609 (95% CI: 5381‐7835‐rate: 30.0; 95% CI: 24.4‐35.6), 4468 (95% CI: 3796‐5102‐rate: 127.6; 95% CI: 108.4‐145.7), 2141 (95% CI: 1585‐2734‐rate: 11.6; 95% CI: 8.6‐14.8), and 339 (95% CI: 224‐459‐rate: 50.0; 95% CI: 36.3‐74.4) among individuals aged <5, ≥5, and ≥65 years, respectively. For these same age groups, the mean annual number of RSV‐associated SARI hospitalizations was 11 768 (95% CI: 10 553‐12 997‐rate: 53.4; 95% CI: 47.9‐59.0), 11 299 (95% CI: 10 350‐12 214‐rate: 322.7; 95% CI: 295.6‐348.8), 469 (95% CI: 203‐783‐rate: 2.5;95% CI: 1.1‐4.2), and 36 (95% CI: 0‐84‐rate: 5.8; 0.0‐13.5), respectively.
  
  Conclusion
  
  The burden of influenza‐ and RSV‐associated SARI hospitalization was high among children aged <5 years. These first estimates for Madagascar will enable government to make informed evidence‐based decisions when allocating scarce resources and planning intervention strategies to limit the impact and spread of these viruses.
  
  
• Subjects:
  Acute Disease Adolescent Adult Aged Child Child, Preschool Cost Of Illness Female Hospitalization Humans Infant Influenza, Human Male Middle Aged Original Article Respiratory Syncytial Virus Infections Retrospective Studies Risk Factors Young Adult

  More +
• Source:
  Influenza Other Respir Viruses. 13(2):138-147
• Pubmed ID:
  30596225
• Pubmed Central ID:
  PMC6379640
• Document Type:
  Journal Article
• Funding:
  Institute Pasteur de Madagascar/ ; U51IP000812-05/US Centers for Disease Control and Prevention/ ; 2016/651796-0/World Health Organization/International
• Place as Subject:
  Madagascar
• Volume:
  13
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:50928623b86cc19420b3b2773e94dda1f4a63bf612e4b7e18034621dc93275d8
• Download URL:
  https://stacks.cdc.gov/view/cdc/77370/cdc_77370_DS1.pdf
• File Type:
  [PDF - 549.75 KB ]