Francisella tularensis Transmission by Solid Organ Transplantation, 20171

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nelson, Christina A. ; Murua, Christian ; Jones, Jefferson M. ; Mohler, Kelli ; Zhang, Ying ; Wiggins, Landon ; Kwit, Natalie A. ; Respicio-Kingry, Laurel ; Kingry, Luke C. ; Petersen, Jeannine M. ; Brown, Jennifer ; Aslam, Saima ; Krafft, Melissa ; Asad, Shadaba ; Dagher, Hikmat N. ; Ham, John ; Medina-Garcia, Luis H. ; Burns, Kevin ; Kelley, Walter E. ; Hinckley, Alison F. ; Annambhotla, Pallavi ; Carifo, Karen ; Gonzalez, Anthony ; Helsel, Elizabeth ; Iser, Joseph ; Johnson, Michael ; Fritz, Curtis L. ; Basavaraju, Sridhar V.
• Corporate Authors:
  Tularemia in Transplant Recipients Investigation Team
• Description:
  In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected only after blood cultures from the surviving kidney recipient grew Francisella species. The organ donor, a middle-aged man from the southwestern United States, had been hospitalized for acute alcohol withdrawal syndrome, pneumonia, and multiorgan failure. F. tularensis subsp. tularensis (clade A2) was cultured from archived spleen tissue from the donor and blood from both kidney recipients. Whole-genome multilocus sequence typing indicated that the isolated strains were indistinguishable. The heart recipient remained seronegative with negative blood cultures but had been receiving antimicrobial drugs for a medical device infection before transplant. Two lagomorph carcasses collected near the donor's residence were positive by PCR for F. tularensis subsp. tularensis (clade A2). This investigation documents F. tularensis transmission by solid organ transplantation.
• Subjects:
  Blood Donors Female Francisella Tularensis Health Care Surveys Heart Transplantation History, 21St Century Humans Kidney Transplantation Male Middle Aged Organ Transplantation Sentinel Surveillance Tissue Donors Tularemia/Epidemiology Tularemia/Etiology Tularemia/History Tularemia/Transmission

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• Source:
  Emerg Infect Dis. 25(4):767-775
• Pubmed ID:
  30730826
• Pubmed Central ID:
  PMC6433034
• Document Type:
  Journal Article
• Genre:
  Historical Article
• Place as Subject:
  United States
• Location:
  North America
• Volume:
  25
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:dd072513310f9531fb6a7a840fa6000e103401351cc8f35eda578aef37fb873d
• Download URL:
  https://stacks.cdc.gov/view/cdc/77161/cdc_77161_DS1.pdf
• File Type:
  [PDF - 1.55 MB ]