Human-Origin Influenza A(H3N2) Reassortant Viruses in Swine, Southeast Mexico

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nelson, Martha I. ; Souza, Carine K. ; Trovão, Nídia S. ; Diaz, Andres ; Mena, Ignacio ; Rovira, Albert ; Vincent, Amy L. ; Torremorell, Montserrat ; Marthaler, Douglas ; Culhane, Marie R.
• Description:
  The genetic diversity of influenza A viruses circulating in swine in Mexico complicates control efforts in animals and presents a threat to humans, as shown by influenza A(H1N1)pdm09 virus. To describe evolution of swine influenza A viruses in Mexico and evaluate strains for vaccine development, we sequenced the genomes of 59 viruses and performed antigenic cartography on strains from 5 regions. We found that genetic and antigenic diversity were particularly high in southeast Mexico because of repeated introductions of viruses from humans and swine in other regions in Mexico. We identified novel reassortant H3N2 viruses with genome segments derived from 2 different viruses that were independently introduced from humans into swine: pandemic H1N1 viruses and seasonal H3N2 viruses. The Mexico swine viruses are antigenically distinct from US swine lineages. Protection against these viruses is unlikely to be afforded by US virus vaccines and would require development of new vaccines specifically targeting these diverse strains.
• Subjects:
  Amals Antigens, Viral / Immunology Humans Influenza A Virus, H1N1 Subtype Influenza Vaccines Orthomyxoviridae Infections Reassortant Viruses Research Swine
• Source:
  Emerg Infect Dis. 25(4):691-700
• Pubmed ID:
  30730827
• Pubmed Central ID:
  PMC6433011
• Document Type:
  Journal Article
• Place as Subject:
  Mexico
• Volume:
  25
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:bf6ed94cd6ad91905d972ec4f684d0bd18d14a86179f1083595d867ef78904f1
• Download URL:
  https://stacks.cdc.gov/view/cdc/77136/cdc_77136_DS1.pdf
• File Type:
  [PDF - 3.21 MB ]