Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015–2017

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Trung, Nguyen Vu ; Hoi, Le Thi ; Dien, Vu Minh ; Huong, Dang Thi ; Hoa, Tran Mai ; Lien, Vu Ngoc ; Van Luan, Phan ; Lewycka, Sonia Odette ; Choisy, Marc ; Bryant, Juliet E. ; Nadjm, Behzad ; Rogier van Doorn, H. ; Richards, Allen L. ; Van Kinh, Nguyen
• Description:
  Rickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine typhus in northern Vietnam and to assess the diagnostic applicability of quantitative real-time PCR assays to diagnose rickettsial diseases. We enrolled 302 patients with acute undifferentiated fever and clinically suspected rickettsiosis during March 2015-March 2017. We used a standardized case report form to collect clinical information and laboratory results at the time of admission and during treatment. We confirmed scrub typhus in 103 (34.1%) patients and murine typhus in 12 (3.3%) patients. These results highlight the need for increased emphasis on training for healthcare providers for earlier recognition, prevention, and treatment of rickettsial diseases in Vietnam.
• Subjects:
  Adult Early Diagnosis Female Humans Male Middle Aged Pathology, Molecular Prospective Studies Scrub Typhus Serotyping Typhus, Endemic Flea-Borne

  More +
• Source:
  Emerg Infect Dis. 25(4):633-641
• Pubmed ID:
  30882318
• Pubmed Central ID:
  PMC6433017
• Document Type:
  Journal Article
• Place as Subject:
  Vietnam
• Volume:
  25
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:70f571408d4dcd62e82ed465191534685d2d94d5fb2e152da16156a0fa548f47
• Download URL:
  https://stacks.cdc.gov/view/cdc/77131/cdc_77131_DS1.pdf
• File Type:
  [PDF - 943.26 KB ]