Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Campbell, Jonathon R. ; Johnston, James C. ; Cook, Victoria J. ; Sadatsafavi, Mohsen ; Elwood, R. Kevin ; ... More +
Campbell, Jonathon R. ; Johnston, James C. ; Cook, Victoria J. ; Sadatsafavi, Mohsen ; Elwood, R. Kevin ; Marra, Fawziah Less -
Description:
Prospective migrants to countries where the incidence of tuberculosis (TB) is low (low-incidence countries) receive TB screening; however, screening for latent TB infection (LTBI) before immigration is rare. We evaluated the cost-effectiveness of mandated and sponsored preimmigration LTBI screening for migrants to low-incidence countries. We used discrete event simulation to model preimmigration LTBI screening coupled with postarrival follow-up and treatment for those who test positive. Preimmigration interferon-gamma release assay screening and postarrival rifampin treatment was preferred in deterministic analysis. We calculated cost per quality-adjusted life-year gained for migrants from countries with different TB incidences. Our analysis provides evidence of the cost-effectiveness of preimmigration LTBI screening for migrants to low-incidence countries. Coupled with research on sustainability, acceptability, and program implementation, these results can inform policy decisions.
Subject:
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Cost-Benefit Analysis
Emigration And Immigration
Humans
Incidence
Interferon-gamma Release Tests
Latent Tuberculosis
Mass Screening
Quality-Adjusted Life Years
Sensitivity And Specificity
Transients And Migrants
Tuberculin Test

Source:
Emerg Infect Dis. 25(4):661-671
Pubmed ID:
30882302
Pubmed Central ID:
PMC6433018
Document Type:
Journal Article
Place as Subject:
Canada
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:d63d22d19358f83012a74e86c6fd04286142c6b27dd3772a49bb2f5289981041
File Type:

Supporting Files

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