Urinary Phthalate Metabolite Concentrations in Relation to Levels of Circulating Matrix Metalloproteinases in Pregnant Women

Bedrosian, Leah D.; Ferguson, Kelly K.; Cantonwine, David E.; McElrath, Thomas F.; Meeker, John D.

doi:10.1016/j.scitotenv.2017.09.244

i

Urinary Phthalate Metabolite Concentrations in Relation to Levels of Circulating Matrix Metalloproteinases in Pregnant Women

Supporting Files

September 28 2017
By Bedrosian, Leah D. ; Ferguson, Kelly K. ; Cantonwine, David E. ; ...

File Language:

English

Details

Alternative Title:

Sci Total Environ
Personal Author:

Bedrosian, Leah D. ; Ferguson, Kelly K. ; Cantonwine, David E. ; McElrath, Thomas F. ; Meeker, John D.
Description:

Phthalate exposure has been shown to be associated with adverse pregnancy outcomes. However, human studies informing relevant mechanistic pathways are lacking. Experimental studies have reported that matrix metalloproteinases (MMPs), which are responsible for extracellular protein degradation, may be upregulated in response to phthalate exposure. In this exploratory study we measured urinary phthalate metabolite concentrations, plasma MMP levels, and relevant covariates among 134 pregnant women. There were statistically significant or suggestive positive relationships between several phthalates, particularly between metabolites of di-(2-ethylhexyl) phthalate, with MMP-1 and MMP-9 levels. Further research is needed to confirm these results and how they may inform the mechanisms involved between phthalate exposure and adverse pregnancy outcomes.
Subjects:

Article Biomarker Environment Enzyme Epidemiology Exposure Female Humans Matrix Metalloproteinase 1 Matrix Metalloproteinase 9 Matrix Metalloproteinases Phthalic Acids Pregnancy Pregnant Women
Source:

Sci Total Environ. 613-614:1349-1352
Pubmed ID:

28968947
Pubmed Central ID:

PMC5681360
Document Type:

Journal Article
Funding:

P42 ES017198/ES/NIEHS NIH HHS/United States ; P50 ES026049/ES/NIEHS NIH HHS/United States ; ZIA ES103321-01/NULL/Intramural NIH HHS/United States ; T42 OH008455/OH/NIOSH CDC HHS/United States ; U2C ES026553/ES/NIEHS NIH HHS/United States ; R01 ES018872/ES/NIEHS NIH HHS/United States ; P30 ES017885/ES/NIEHS NIH HHS/United States
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:e6bb6df9530be7a8148c130756091e19b502da9c21c2e55cc2e16c95c5680569
Download URL:

https://stacks.cdc.gov/view/cdc/77049/cdc_77049_DS1.pdf
File Type:

[PDF - 384.21 KB ]

File Language:

English

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