Clinical and Radiologic Characteristics of Human Metapneumovirus Infections in Adults, South Korea

Koo, Hyun Jung; Lee, Han Na; Choi, Sang Ho; Sung, Heungsup; Kim, Hwa Jung; Do, Kyung-Hyun

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Clinical and Radiologic Characteristics of Human Metapneumovirus Infections in Adults, South Korea

Supporting Files Public Domain

January 2019
By Koo, Hyun Jung ; Lee, Han Na ; Choi, Sang Ho ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Koo, Hyun Jung ; Lee, Han Na ; Choi, Sang Ho ; Sung, Heungsup ; Kim, Hwa Jung ; Do, Kyung-Hyun
Description:

Clinical features of human metapneumovirus (HMPV) infection have not been well documented for adults. We investigated clinical and radiologic features of HMPV infection in 849 adults in a tertiary hospital in South Korea. We classified patients into groups on the basis of underlying diseases: immunocompetent patients, solid tumor patients, solid organ transplantation recipients, hematopoietic stem cell transplant recipients, hematologic malignancy patients, and patients receiving long-term steroid treatment. Of 849 HMPV-infected patients, 756 had community-acquired infections, 579 had pneumonia, and 203 had infections with other pathogens. Mortality rates were highest in hematopoietic stem cell transplantation recipients (22% at 30 days). Older age, current smoking, and underlying disease were associated with HMPV pneumonia. Body mass index and an immunocompromised state were associated with 30-day mortality rates in HMPV-infected patients. Bronchial wall thickening, ground-glass opacity, and ill-defined centrilobular nodules were common computed tomography findings for HMPV pneumonia. Macronodules and consolidation were observed in <50% of patients.
Subjects:

Aged Community-Acquired Infections Female Hematologic Neoplasms Hematopoietic Stem Cell Transplantation Humans Immunocompromised Host Male Metapneumovirus Middle Aged Organ Transplantation Paramyxoviridae Infections Pneumonia, Viral Synopsis Tertiary Care Centers Tomography, X-Ray Computed
Source:

Emerg Infect Dis. 25(1):15-24
Pubmed ID:

30560776
Pubmed Central ID:

PMC6302610
Document Type:

Journal Article
Place as Subject:

Republic of Korea
Location:

Asia
Volume:

25
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:ea9619a5e48e8bad6c9e45e5c00880aed97e043cefbb110721ea98e2d6950bdc
Download URL:

https://stacks.cdc.gov/view/cdc/76872/cdc_76872_DS1.pdf
File Type:

[PDF - 1.50 MB ]

File Language:

English

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