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Zika Virus Epidemic in Pregnant Women, Dominican Republic, 2016–2017
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Feb 2019
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Source: Emerg Infect Dis. 25(2):247-255
[PDF-2.59 MB]
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Alternative Title:Emerg Infect Dis
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Description:Zika virus infection during pregnancy may result in birth defects and pregnancy complications. We describe the Zika virus outbreak in pregnant women in the Dominican Republic during 2016-2017. We conducted multinomial logistic regression to identify factors associated with fetal losses and preterm birth. The Ministry of Health identified 1,282 pregnant women with suspected Zika virus infection, a substantial proportion during their first trimester. Fetal loss was reported for ≈10% of the reported pregnancies, and 3 cases of fetal microcephaly were reported. Women infected during the first trimester were more likely to have early fetal loss (adjusted odds ratio 5.9, 95% CI 3.5-10.0). Experiencing fever during infection was associated with increased odds of premature birth (adjusted odds ratio 1.65, 95% CI 1.03-2.65). There was widespread morbidity during the epidemic. Our findings strengthen the evidence for a broad range of adverse pregnancy outcomes resulting from Zika virus infection.
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Pubmed ID:30666928
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Pubmed Central ID:PMC6346438
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Volume:25
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Issue:2
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