Zika Virus Epidemic in Pregnant Women, Dominican Republic, 2016–2017

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Peña, Farah ; Pimentel, Raquel ; Khosla, Shaveta ; Mehta, Supriya D. ; Brito, Maximo O.
• Description:
  Zika virus infection during pregnancy may result in birth defects and pregnancy complications. We describe the Zika virus outbreak in pregnant women in the Dominican Republic during 2016-2017. We conducted multinomial logistic regression to identify factors associated with fetal losses and preterm birth. The Ministry of Health identified 1,282 pregnant women with suspected Zika virus infection, a substantial proportion during their first trimester. Fetal loss was reported for ≈10% of the reported pregnancies, and 3 cases of fetal microcephaly were reported. Women infected during the first trimester were more likely to have early fetal loss (adjusted odds ratio 5.9, 95% CI 3.5-10.0). Experiencing fever during infection was associated with increased odds of premature birth (adjusted odds ratio 1.65, 95% CI 1.03-2.65). There was widespread morbidity during the epidemic. Our findings strengthen the evidence for a broad range of adverse pregnancy outcomes resulting from Zika virus infection.
• Subjects:
  Adolescent Adult Child Cross-Sectional Studies Disease Outbreaks Epidemics Female History, 21St Century Humans Pregnancy Pregnancy Complications, Infectious/Epidemiology Pregnancy Complications, Infectious/History Pregnancy Complications, Infectious/Virology Pregnancy Outcome Public Health Surveillance Risk Factors Young Adult Zika Virus Zika Virus Infection/Diagnosis Zika Virus Infection/Epidemiology Zika Virus Infection/History Zika Virus Infection/Virology

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• Source:
  Emerg Infect Dis. 25(2):247-255
• Pubmed ID:
  30666928
• Pubmed Central ID:
  PMC6346438
• Document Type:
  Journal Article
• Genre:
  Historical Article
• Place as Subject:
  Dominican Republic
• Location:
  Caribbean
• Volume:
  25
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:bad474fa1b6097d4253cee8e2e1a496388dec1443ae158a17cb1a0368677832b
• Download URL:
  https://stacks.cdc.gov/view/cdc/76797/cdc_76797_DS1.pdf
• File Type:
  [PDF - 2.59 MB ]