Maternal Dietary Supplement Use and Development of Islet Autoimmunity in the offspring: the TEDDY Study

Details

• Alternative Title:
  Pediatr Diabetes
• Personal Author:
  Silvis, Katherine ; Andrén Aronsson, Carin ; Liu, Xiang ; Uusitalo, Ulla ; Yang, Jimin ; Tamura, Roy ; Lernmark, Åke ; Rewers, Marian ; Hagopian, William ; She, Jin-Xiong ; Simell, Olli ; Toppari, Jorma ; Ziegler, Anette ; Akolkar, Beena ; Krischer, Jeffrey ; Virtanen, Suvi M ; Norris, Jill M.
• Corporate Authors:
  TEDDY Study Group
• Description:
  Objective:
  
  We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring.
  
  Methods:
  
  The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the US. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3–4 months postpartum. Cumulative intakes of supplemental vitamin D and n-3 FAs were analyzed as continuous or binary variables. We applied time-to-event analysis to study the association between maternal supplement use and IA, adjusting for country, HLA DR-DQ genotype, family history of type 1 diabetes and sex. Secondary outcomes included IAA or GADA as the first appearing autoantibody.
  
  Results:
  
  As of February 2018, there were 747 (9.0%) children with IA. Vitamin D supplement intake during pregnancy (any vs none) was not associated with risk for IA (hazard ratio (HR) 1.11; 95% CI 0.94, 1.31); neither was cumulative vitamin D supplement intake. Supplemental n-3 FA intake was similarly not associated with IA risk (HR: 1.19, 95% CI 0.98, 1.45). Similar lack of association was observed for either IAA or GADA as the first appearing autoantibody.
  
  Conclusions:
  
  The TEDDY cohort showed no evidence of benefit regarding IA risk for vitamin D or n-3 FA supplementation during pregnancy.
  
  
• Subjects:
  Autoantibodies Autoimmunity Child Child, Preschool Diabetes Mellitus, Type 1 Dietary Supplements Fatty Acids, Omega-3 Female Glutamate Decarboxylase Humans Infant Islets Of Langerhans Male Maternal Nutritional Physiological Phenomena Pregnancy Prenatal Exposure Delayed Effects Vitamin D

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• Source:
  Pediatr Diabetes. 20(1):86-92
• Pubmed ID:
  30411443
• Pubmed Central ID:
  PMC6341488
• Document Type:
  Journal Article
• Funding:
  U01 DK063821/DK/NIDDK NIH HHS/United States ; UC4 DK063863/DK/NIDDK NIH HHS/United States ; JDRF/Juvenile Diabetes Research Foundation/United States ; UL1 TR002535/TR/NCATS NIH HHS/United States ; HHSN267200700014C/DK/NIDDK NIH HHS/United States ; U01 DK063861/DK/NIDDK NIH HHS/United States ; UL1 TR001427/TR/NCATS NIH HHS/United States ; U01 DK063790/DK/NIDDK NIH HHS/United States ; UL1 TR001082/TR/NCATS NIH HHS/United States ; UL1 TR000064/TR/NCATS NIH HHS/United States ; HHSN267200700014C/LM/NLM NIH HHS/United States ; U01 DK063836/DK/NIDDK NIH HHS/United States ; U01 DK063829/DK/NIDDK NIH HHS/United States ; U01 DK063865/DK/NIDDK NIH HHS/United States ; UC4 DK095300/DK/NIDDK NIH HHS/United States ; UC4 DK063861/DK/NIDDK NIH HHS/United States ; UC4 DK063829/DK/NIDDK NIH HHS/United States ; UC4 DK063821/DK/NIDDK NIH HHS/United States ; UC4 DK117483/DK/NIDDK NIH HHS/United States ; UC4 DK063836/DK/NIDDK NIH HHS/United States ; UC4 DK112243/DK/NIDDK NIH HHS/United States ; UC4 DK063865/DK/NIDDK NIH HHS/United States ; U01 DK063863/DK/NIDDK NIH HHS/United States ; UC4 DK106955/DK/NIDDK NIH HHS/United States ; UC4 DK100238/DK/NIDDK NIH HHS/United States ; P30 DK017047/DK/NIDDK NIH HHS/United States ; CC/CDC HHS/United States
• Place as Subject:
  Finland ; Germany ; Sweden ; United States
• Volume:
  20
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b81a9018f7e6fec766eaefdc8c93503560fbfaef7f4637ce4e96f0ba304f3d39
• Download URL:
  https://stacks.cdc.gov/view/cdc/76745/cdc_76745_DS1.pdf
• File Type:
  [PDF - 322.81 KB ]