Vitamin D and albuminuria in youth with and without type 1 diabetes

Details

• Alternative Title:
  Horm Res Paediatr
• Personal Author:
  Nandi-Munshi, Debika ; Afkarian, Maryam ; Whitlock, Kathryn B. ; Crandell, Jamie L. ; Bell, Ronny A. ; D’Agostino, Ralph ; Saydah, Sharon ; Mottl, Amy K. ; Dabelea, Dana ; Black, Mary Helen ; Mayer-Davis, Elizabeth J ; Pihoker, Catherine
• Description:
  BACKGROUND/AIMS
  
  In adults, lower Vitamin D has been associated with increased albuminuria. This association has not been extensively studied in youth with or without type 1 diabetes.
  
  METHODS
  
  We examined the cross-sectional association between vitamin D and albuminuria (urine albumin/creatinine ratio [ACR] ≥30 mg/g) in 8,789 participants of the National Health and Nutrition Survey 2001–2006 (NHANES), who were 6-19 years old. Further, we examined the association between vitamin D and albuminuria in 938 participants from the SEARCH Nutritional Ancillary Study (SNAS), a longitudinal cohort of youth with type 1 diabetes.
  
  RESULTS
  
  In NHANES, 5.3%, 19.5%, and 53.7% had vitamin D levels less than 30, 50 and 80 nmol/L. Albuminuria was present in 12.8% and was more common in younger children, females, non-Hispanic whites, non-obese children, and children with hypertension. After adjustments, there was no association between vitamin D and albuminuria. In SNAS participants with type 1 diabetes, we also found no association between baseline vitamin D and subsequent albuminuria, in unadjusted or adjusted analyses.
  
  CONCLUSION
  
  We did not find an association between serum vitamin D and albuminuria in either non-diabetic youth or those with type 1 diabetes. Further research is needed to more fully understand this relationship.
  
  
• Subjects:
  Adolescent Adult Age Factors Albuminuria Child Diabetes Complications Diabetes Mellitus, Type 1 Female Humans Male Sex Factors Vitamin D

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• Keywords:
  Adolescents Children Type 1 Diabetes
• Source:
  Horm Res Paediatr. 87(6):385-395
• Pubmed ID:
  28554178
• Pubmed Central ID:
  PMC5568007
• Document Type:
  Journal Article
• Funding:
  P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR000154/TR/NCATS NIH HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; M01 RR000037/RR/NCRR NIH HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006134/ACL/ACL HHSUnited States/ ; UL1 RR029882/RR/NCRR NIH HHSUnited States/ ; U18DP006131/ACL/ACL HHSUnited States/ ; P30 DK056350/DK/NIDDK NIH HHSUnited States/ ; K23 DK089017/DK/NIDDK NIH HHSUnited States/ ; UL1 TR000423/TR/NCATS NIH HHSUnited States/ ; U18DP006139/ACL/ACL HHSUnited States/ ; UC4 DK108173/DK/NIDDK NIH HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; R01 DK077949/DK/NIDDK NIH HHSUnited States/ ; U18DP006138/ACL/ACL HHSUnited States/ ; M01 RR000069/RR/NCRR NIH HHSUnited States/ ; K23 DK093804/DK/NIDDK NIH HHSUnited States/ ; EP-C-15-002/EPA/EPAUnited States/ ; U18 DP006136/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR001425/TR/NCATS NIH HHSUnited States/ ; UL1 TR002319/TR/NCATS NIH HHSUnited States/ ; U18DP006136/ACL/ACL HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR001450/TR/NCATS NIH HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; UL1 RR026314/RR/NCRR NIH HHSUnited States/ ; U18DP006133/ACL/ACL HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  87
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:53752c5e717a4dbaec2303031bbae731cc4c6e7c7217e74309216eb06b86360fab73f95f2cfa978540704637803082c388e740a157ddddf2dd8c3a7dbe0132d5
• Download URL:
  https://stacks.cdc.gov/view/cdc/47730/cdc_47730_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]