Increased Risk for Invasive Group A Streptococcus Disease for Household Contacts of Scarlet Fever Cases, England, 2011–2016

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• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Watts, Vicky ; Balasegaram, Sooria ; Brown, Colin S. ; Mathew, Suzanna ; Mearkle, Rachel ; Ready, Derren ; Saliba, Vanessa ; Lamagni, Theresa
• Description:
  The incidence of scarlet fever in England and Wales is at its highest in 50 years. We estimated secondary household risk for invasive group A Streptococcus (iGAS) disease within 60 days after onset of scarlet fever. Reports of scarlet fever in England during 2011-2016 were matched by residential address to persons with laboratory-confirmed iGAS infections. We identified 11 iGAS cases in ≈189,684 household contacts and a 60-day incidence rate of 35.3 cases/100,000 person-years, which was 12.2-fold higher than the background rate (2.89). Infants and contacts >75 years of age were at highest risk. Three cases were fatal; sepsis and cellulitis were the most common manifestations. Typing for 6 iGAS cases identified emm 1.0 (n = 4), emm 4.0 (n = 1), and emm 12.0 (n = 1). Although absolute risk in household contacts was low, clinicians assessing household contacts should be aware of the risk to expedite diagnosis and initiate life-saving treatment.
• Subjects:
  Bacteria Household Contacts IGAS Disease Incidence Invasive Group A Streptococcus Disease Invasive Group A Streptococcus Disease For Household Contacts Of Scarlet Fever Cases, England, 2011–2016 Research Respiratory Infections Risk Scarlet Fever Streptococcal Infections Streptococci Streptococcus Pyogenes

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• Source:
  Emerg Infect Dis. 25(3):529-537
• Pubmed ID:
  30602121
• Pubmed Central ID:
  PMC6390732
• Document Type:
  Journal Article
• Place as Subject:
  England
• Location:
  Europe
• Volume:
  25
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a4fa6ba69620b196995ed8b27f6668b592cd2fd8e2a96a5844de91f70a183a47
• Download URL:
  https://stacks.cdc.gov/view/cdc/76659/cdc_76659_DS1.pdf
• File Type:
  [PDF - 968.40 KB ]