Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Lee, Hyukmin ; Suh, Young Hee ; Lee, Sunhwa ; Kim, Yong-Kyun ; Han, Mi-Soon ; ... More +
Lee, Hyukmin ; Suh, Young Hee ; Lee, Sunhwa ; Kim, Yong-Kyun ; Han, Mi-Soon ; Bae, Hye Gyung ; Unemo, Magnus ; Lee, Kyungwon Less -
Description:
In South Korea, surveillance of antimicrobial drug resistance in Neisseria gonorrhoeae is extremely limited. We describe the emergence and subsequent national spread of N. gonorrhoeae strains with mosaic penA alleles associated with decreased susceptibility and resistance to extended-spectrum cephalosporins. From 2012 through 2017, the proportion of mosaic penA alleles in gonococcal-positive nucleic acid amplification test (NAAT) specimens across South Korea increased from 1.1% to 23.9%. Gonococcal strains with mosaic penA alleles emerged in the international hubs of Seoul in Gyeonggi Province and Busan in South Gyeongsang Province and subsequently spread across South Korea. Most common was mosaic penA-10.001 (n = 572 isolates; 94.7%), which is associated with cefixime resistance. We also identified mosaic penA-34.001 and penA-60.001, both of which are associated with multidrug-resistant gonococcal strains and spread of cefixime and ceftriaxone resistance. Implementation of molecular resistance prediction from N. gonorrhoeae-positive nucleic acid amplification test specimens is imperative in South Korea and internationally.
Subjects:
[+]
AMR Antimicrobial Resistance Antimicrobial Treatment Bacteria Cefixime Ceftriaxone Cephalosporin Gonorrhea MLST Neisseria Gonorrhoeae NG-MAST PenA Research Sexually Transmitted Infections
Source:
Emerg Infect Dis. 25(3):416-424
Pubmed ID:
30789143
Pubmed Central ID:
PMC6390772
Document Type:
Journal Article
Place as Subject:
Republic of Korea
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:75038a40e91953a53432c38fa5dff30812cc3f3034dba1c8ca00bc5697f31879
Download URL:
https://stacks.cdc.gov/view/cdc/76658/cdc_76658_DS1.pdf
File Type:

Supporting Files

• 	18-1503-F1.gif	gif
  	18-1503-F1.jpg	jpeg
  	18-1503-F2.gif	gif
  	18-1503-F2.jpg	jpeg
  	18-1503.nxml	xml

More +