Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010–2012

Lande, Leah; Alexander, David C.; Wallace, Richard J.; Kwait, Rebecca; Iakhiaeva, Elena; Williams, Myra; Cameron, Andrew D.S.; Olshefsky, Stephen; Devon, Ronit; Vasireddy, Ravikiran; Peterson, Donald D.; Falkinham, Joseph O.

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Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010–2012

Supporting Files Public Domain

Mar 2019
By Lande, Leah ; Alexander, David C. ; Wallace, Richard J.

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Lande, Leah ; Alexander, David C. ; Wallace, Richard J. ; Kwait, Rebecca ; Iakhiaeva, Elena ; Williams, Myra ; Cameron, Andrew D.S. ; Olshefsky, Stephen ; Devon, Ronit ; Vasireddy, Ravikiran ; Peterson, Donald D. ; Falkinham, Joseph O.
Description:

Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable-number tandem-repeat genotyping and whole-genome sequencing with core genome single-nucleotide variant analysis to compare M. avium from household plumbing biofilms with M. avium isolates from patient respiratory specimens. M. avium was recovered from 30 (81.1%) of 37 households, including 19 (90.5%) of 21 M. avium patient households. For 11 (52.4%) of 21 patients with M. avium disease, isolates recovered from their respiratory and household samples were of the same genotype. Within the same community, 18 (85.7%) of 21 M. avium respiratory isolates genotypically matched household plumbing isolates. Six predominant genotypes were recovered across multiple households and respiratory specimens. M. avium colonizing municipal water and household plumbing may be a substantial source of MAC pulmonary infection.
Subjects:
Source:

Emerg Infect Dis. 25(3):473-481
Pubmed ID:

30789130
Pubmed Central ID:

PMC6390762
Document Type:

Journal Article
Genre:

Historical Article
Place as Subject:

Philadelphia, PA ; Pennsylvania
Volume:

25
Issue:

3
Download URL:

https://stacks.cdc.gov/view/cdc/76632/cdc_76632_DS1.pdf
File Type:

[PDF - 1.03 MB]
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:354e4e0de073592c438cf3aa7b98a790950a508c62bd6487f531f4d4cc7c0348

File Language:

English

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