Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010–2012

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lande, Leah ; Alexander, David C. ; Wallace, Richard J. ; Kwait, Rebecca ; Iakhiaeva, Elena ; Williams, Myra ; Cameron, Andrew D.S. ; Olshefsky, Stephen ; Devon, Ronit ; Vasireddy, Ravikiran ; Peterson, Donald D. ; Falkinham, Joseph O.
• Description:
  Attention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable-number tandem-repeat genotyping and whole-genome sequencing with core genome single-nucleotide variant analysis to compare M. avium from household plumbing biofilms with M. avium isolates from patient respiratory specimens. M. avium was recovered from 30 (81.1%) of 37 households, including 19 (90.5%) of 21 M. avium patient households. For 11 (52.4%) of 21 patients with M. avium disease, isolates recovered from their respiratory and household samples were of the same genotype. Within the same community, 18 (85.7%) of 21 M. avium respiratory isolates genotypically matched household plumbing isolates. Six predominant genotypes were recovered across multiple households and respiratory specimens. M. avium colonizing municipal water and household plumbing may be a substantial source of MAC pulmonary infection.
• Subjects:
  Aged Aged, 80 And Over Environmental Microbiology Female Genotype History, 21St Century Humans Male Middle Aged Minisatellite Repeats Multilocus Sequence Typing Mycobacterium Avium Mycobacterium Avium-Intracellulare Infection/Epidemiology Mycobacterium Avium-Intracellulare Infection/History Mycobacterium Avium-Intracellulare Infection/Microbiology Mycobacterium Avium Complex Phylogeny Public Health Surveillance Water Microbiology Whole Genome Sequencing

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• Source:
  Emerg Infect Dis. 25(3):473-481
• Pubmed ID:
  30789130
• Pubmed Central ID:
  PMC6390762
• Document Type:
  Journal Article
• Genre:
  Historical Article
• Place as Subject:
  Philadelphia, PA ; Pennsylvania
• Volume:
  25
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:354e4e0de073592c438cf3aa7b98a790950a508c62bd6487f531f4d4cc7c0348
• Download URL:
  https://stacks.cdc.gov/view/cdc/76632/cdc_76632_DS1.pdf
• File Type:
  [PDF - 1.03 MB ]