HIV Drug Resistance among Pre-treatment Cases in Thailand: Four Rounds of Surveys during 2006-2013

Details

• Alternative Title:
  Outbreak Surveill Investig Rep
• Personal Author:
  Thanprasertsuk, Sombat ; Phokhasawad, Kunjanakorn ; Teeraratkul, Achara ; Chasombat, Sanchai ; Pattarapayoon, Naparat ; Saeng-aroon, Siriphan ; Yuktanon, Porntip ; Kohreanudom, Surapol ; Lertpiriyasuwat, Cheewanan
• Description:
  In Thailand, antiretroviral therapy (ART) was initiated to treat human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) cases using the empirical regimen with no prior genotypic test to determine drug resistance. In order to assess prevalence rate of HIV drug resistance (HIVDR) among pre-treatment cases, four rounds of survey were carried out in ART clinics, including six, eight, 33 and four ART clinics in each round during 2006-2013. For which, HIVDR testing results were available in 310, 350, 797, and 413 cases in four rounds. It was revealed that HIVDR rates among naive cases were 2.0%, 2.8%, 4.0% and 4.8%, while in experienced cases, the rates were 0, 3.3%, 11.4% and 13.9%. The rates among all cases were 1.9%, 2.9%, 4.4% and 5.6%. Resistant drugs with the highest rates among all cases in the survey round 4 were nevirapine (3.6%) and efavirenz (3.1%). The results indicated the need to continue surveillance for pre-treatment HIVDR, and posed challenges to implement activities for protecting efficacy and prolong the use of empirical first-line regimen. A strategy to apply genotyping test, in a cost-effective approach, should be considered to prepare for situation when HIVDR increases beyond a critical level.
• Keywords:
  Antiretroviral Therapy HIV Pre-treatment Resistance Thailand
• Source:
  Outbreak Surveill Investig Rep. 11(1):6-13
• Pubmed ID:
  30847451
• Pubmed Central ID:
  PMC6400074
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  11
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b107aba5445eead24da6e1e9c662c5bfe8ff042c460453722fa0bfc3a3c25df1
• Download URL:
  https://stacks.cdc.gov/view/cdc/76442/cdc_76442_DS1.pdf
• File Type:
  [PDF - 327.08 KB ]