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Repeated Iron-Soot Exposure and Nose-to-Brain Transport of Inhaled Ultrafine Particles
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1 2018
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Source: Toxicol Pathol. 46(1):75-84
[PDF-1.26 MB]
Details:
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Alternative Title:Toxicol Pathol
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Personal Author:
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Description:Particulate exposure has been implicated in the development of a number of neurological maladies such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, and idiopathic Parkinson's disease. Only a few studies have focused on the olfactory pathway as a portal through which combustion-generated particles may enter the brain. The primary objective of this study was to define the deposition, uptake, and transport of inhaled ultrafine iron-soot particles in the nasal cavities of mice to determine whether combustion-generated nanoparticles reach the olfactory bulb via the olfactory epithelium and nerve fascicles. Adult female C57B6 mice were exposed to iron-soot combustion particles at a concentration of 200 μg/m|, which included 40 μg/m| of iron oxide nanoparticles. Mice were exposed for 6 hr/day, 5 days/week for 5 consecutive weeks (25 total exposure days). Our findings visually demonstrate that inhaled ultrafine iron-soot reached the brain via the olfactory nerves and was associated with indicators of neural inflammation.
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Pubmed ID:28914166
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Pubmed Central ID:PMC6405220
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Volume:46
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Issue:1
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