Repeated Iron-Soot Exposure and Nose-to-Brain Transport of Inhaled Ultrafine Particles

Details

• Alternative Title:
  Toxicol Pathol
• Personal Author:
  Hopkins, Laurie E. ; Laing, Emilia A. ; Peake, Janice L. ; Uyeminami, Dale ; Mack, Savannah M. ; Li, Xueting ; Smiley-Jewell, Suzette ; Pinkerton, Kent E.
• Description:
  Particulate exposure has been implicated in the development of a number of neurological maladies such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, and idiopathic Parkinson's disease. Only a few studies have focused on the olfactory pathway as a portal through which combustion-generated particles may enter the brain. The primary objective of this study was to define the deposition, uptake, and transport of inhaled ultrafine iron-soot particles in the nasal cavities of mice to determine whether combustion-generated nanoparticles reach the olfactory bulb via the olfactory epithelium and nerve fascicles. Adult female C57B6 mice were exposed to iron-soot combustion particles at a concentration of 200 μg/m|, which included 40 μg/m| of iron oxide nanoparticles. Mice were exposed for 6 hr/day, 5 days/week for 5 consecutive weeks (25 total exposure days). Our findings visually demonstrate that inhaled ultrafine iron-soot reached the brain via the olfactory nerves and was associated with indicators of neural inflammation.
• Subjects:
  Animals Brain Female Ferric Compounds Inhalation Exposure Mice Mice, Inbred C57BL Mucociliary Clearance Nanoparticles Nasal Cavity Olfactory Bulb Olfactory Mucosa Soot

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• Keywords:
  Brain Chlorination Household Water Treatment Iron/Soot Nose Olfactory Epithelium Safe Water Storage Ultrafine Combustion Particles
• Source:
  Toxicol Pathol. 46(1):75-84
• Pubmed ID:
  28914166
• Pubmed Central ID:
  PMC6405220
• Document Type:
  Journal Article
• Funding:
  U50 OH007550/OH/NIOSH CDC HHSUnited States/ ; P51 OD011107/OD/NIH HHSUnited States/ ; T32 ES007059/ES/NIEHS NIH HHSUnited States/ ; P30 ES023513/ES/NIEHS NIH HHSUnited States/ ; U01 ES027288/ES/NIEHS NIH HHSUnited States/ ; U54 OH007550/OH/NIOSH CDC HHSUnited States/
• Volume:
  46
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a610ea02d76bc52692637ad2c4e60ff4a166b4db014ef40d9e11882fb77e2ccf
• Download URL:
  https://stacks.cdc.gov/view/cdc/76382/cdc_76382_DS1.pdf
• File Type:
  [PDF - 1.26 MB ]