Repeated Iron-Soot Exposure and Nose-to-Brain Transport of Inhaled Ultrafine Particles

Details

• Personal Author:
  Hopkins LE ; Laing EA ; Li X ; Mack SM ; Peake JL ; Pinkerton KE ; Smiley-Jewell S ; Uyeminami D
• Description:
  Particulate exposure has been implicated in the development of a number of neurological maladies such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, and idiopathic Parkinson's disease. Only a few studies have focused on the olfactory pathway as a portal through which combustion-generated particles may enter the brain. The primary objective of this study was to define the deposition, uptake, and transport of inhaled ultrafine iron-soot particles in the nasal cavities of mice to determine whether combustion-generated nanoparticles reach the olfactory bulb via the olfactory epithelium and nerve fascicles. Adult female C57B6 mice were exposed to iron-soot combustion particles at a concentration of 200 µg/m3, which included 40 µg/m3 of iron oxide nanoparticles. Mice were exposed for 6 hr/day, 5 days/week for 5 consecutive weeks (25 total exposure days). Our findings visually demonstrate that inhaled ultrafine iron-soot reached the brain via the olfactory nerves and was associated with indicators of neural inflammation. [Description provided by NIOSH]
• Subjects:
  Laboratories Nervous System Nervous System Diseases Nose Occupational Health Particulate Matter Respiratory System Safety Sense Organs
• Keywords:
  Author Keywords: Nose Brain Inhalation Iron Iron Oxides Laboratory Animals Nanoparticles Nasal Cavity Neurological Disorders Olfactory Epithelium Olfactory System Particulates Soot Ultrafine Combustion Particles Ultrafine Particles

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• ISSN:
  0192-6233
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; New York ; OSHA Region 2 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  75-84
• Volume:
  46
• Issue:
  1
• NIOSHTIC Number:
  nn:20053301
• Citation:
  Toxicol Pathol 2018 Jan; 46(1):75-84
• Contact Point Address:
  Kent E. Pinkerton, Center for Health and the Environment, University of California, Davis, Davis, California 95616
• Email:
  kepinkerton@ucdavis.edu
• CAS Registry Number:
  Iron (CAS RN 7439-89-6)
• Federal Fiscal Year:
  2018
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Toxicologic Pathology
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:273f5a818117673482f4b6427f977975e3122d665cfafdacaebd1b47a3dd096dcb59da52d04f3d88848a778fdc71f76aba5b675c5d36220072ce0515177cb292
• Download URL:
  https://stacks.cdc.gov/view/cdc/216091/cdc_216091_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]