Details:

Alternative Title:
Sex Transm Dis
Personal Author:
Cope, Anna B. ; Mobley, Victoria L. ; Oliver, Sara E. ; Larson, Mara ; Dzialowy, Nicole ; ... More +
Cope, Anna B. ; Mobley, Victoria L. ; Oliver, Sara E. ; Larson, Mara ; Dzialowy, Nicole ; Maxwell, Jason ; Rinsky, Jessica L. ; Peterman, Thomas A. ; Fleischauer, Aaron ; Samoff, Erika Less -
Description:
Background:

Ocular syphilis (OS) has been associated with HIV coinfection previously. We compared demographic and clinical characteristics of syphilis patients with and without HIV to identify risk factors for developing OS.

Methods:

We reviewed all syphilis cases (early and late) reported to the North Carolina (NC) Division of Public Health during 2014-2016 and categorized HIV status (positive, negative, unknown) and OS status based on report of ocular symptoms with no other defined etiology. We estimated prevalence ratios (PR) and 95% confidence intervals (CI) for OS by HIV status. Among syphilis patients with HIV, we compared viral loads and CD4 cell counts by OS status. We compared symptom resolution by HIV status for a subset of OS patients.

Results:

Among 7,123 confirmed syphilis cases, 2,846 (39.9%) were living with HIV, 109 (1.5%) had OS, and 59 (0.8%) had both. OS was more prevalent in syphilis patients with HIV compared to HIV-negative/unknown-status patients (PR: 1.8; 95% CI: 1.2, 2.6). Compared to other patients with HIV, the prevalence of OS was higher in patients with viral loads >200 copies/mL (1.7; 1.0, 2.8) and in patients with a CD4 count ≤200 cells/mL (2.3; 1.3, 4.2). Among 11 patients with severe OS, 9 (81.8%) were HIV-positive. Among 39 interviewed OS patients, OS symptom resolution was similar for HIV-positive (70.0%) and HIV-negative/unknown-status (68.4%) patients.

Conclusion:

Syphilis patients with HIV were nearly twice as likely to report OS symptoms as were patients without documented HIV. HIV-related immunodeficiency possibly increases the risk of OS development in co-infected patients.


Subjects:
[+]
Article CD4 Ocular Syphilis And HIV Coinfection Among Syphilis Patients In North Carolina, 2014-2016 Treponema Pallidum Uveitis Viral Load Vision Loss
Source:
Sex Transm Dis. 46(2):80-85
Pubmed ID:
30169474
Pubmed Central ID:
PMC6400053
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Place as Subject:
North Carolina
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:69e96306ce4385cfeee9486f22070763b41fd133425b5ee798da2343792e8dfb
Download URL:
https://stacks.cdc.gov/view/cdc/76298/cdc_76298_DS1.pdf
File Type:

Supporting Files

• 	nihms-1009700.nxml	xml
  	NIHMS1009700-supplement-S1a__S1a.docx	docx

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