Impact of community respiratory viral infections in urban children with asthma

Details

• Alternative Title:
  Ann Allergy Asthma Immunol
• Personal Author:
  Lewis, Toby C. ; Metitiri, Ediri E. ; Mentz, Graciela B. ; Ren, Xiaodan ; Goldsmith, Adam M. ; Eder, Breanna N. ; Wicklund, Kyra E. ; Walsh, Megan P. ; Comstock, Adam T. ; Ricci, Jeannette M. ; Brennan, Sean R. ; Washington, Ginger L. ; Owens, Kendall B. ; Mukherjee, Bhramar ; Robins, Thomas G. ; Batterman, Stuart A. ; Hershenson, Marc B.
• Corporate Authors:
  Community Action Against Asthma Steering Committee
• Description:
  Background:
  
  Upper respiratory tract viral infections cause asthma exacerbations in children. However, the impact of natural colds on asthmatic children in the community, particularly in the high-risk urban environment, is less well-defined.
  
  Objective:
  
  We hypothesized that children with high-symptom upper respiratory viral infections have reduced airway function and greater respiratory tract inflammation than children with virus-positive low-symptom illnesses or virus-negative upper respiratory tract symptoms.
  
  Methods:
  
  We studied 53 asthmatic children from Detroit, Michigan during scheduled surveillance periods and self-reported respiratory illnesses for one year. Symptom score, spirometry, fraction of exhaled nitric oxide (FeNO) and nasal aspirate biomarkers, viral nucleic acid and rhinovirus (RV) copy number were assessed.
  
  Results:
  
  Of 658 aspirates collected, 22.9% of surveillance samples and 33.7% of respiratory illnesses were virus-positive. Compared to the virus-negative asymptomatic condition, children with severe colds (symptom score ≥5) showed reduced forced expiratory flow at 25–75% of the pulmonary volume (FEF25–75), higher nasal mRNA expression of C-X-C motif chemokine ligand (CXCL)-10 and melanoma differentiation-associated protein 5, and higher protein abundance of CXCL8, CXCL10 and C-C motif chemokine ligands (CCL)-2, CCL4, CCL20 and CCL24. Children with mild (symptom score 1–4) and asymptomatic infections showed normal airway function and fewer biomarker elevations. Virus-negative cold-like illnesses demonstrated increased FeNO, minimal biomarker elevation and normal airflow. RV copy number was associated with nasal chemokine levels but not symptom score.
  
  Conclusion:
  
  Urban asthmatic children with high-symptom respiratory viral infections have reduced FEF25–75 and more elevations of nasal biomarkers than children with mild or asymptomatic infections, or virus-negative illnesses.
  
  
• Subjects:
  Asthma Black Or African American Chemokine CXCL10 Child Community-Acquired Infections Female Humans Male Respiratory Tract Infections Viral Load Virus Diseases

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• Keywords:
  Chemokine Chlorination Cold Exhaled Nitric Oxide Household Water Treatment MDA5 Nasal Rhinovirus Safe Water Storage Spirometry Urban Viral Load

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• Source:
  Ann Allergy Asthma Immunol. 122(2):175-183.e2
• Pubmed ID:
  30385348
• Pubmed Central ID:
  PMC6360098
• Document Type:
  Journal Article
• Funding:
  T42 OH008455/OH/NIOSH CDC HHSUnited States/ ; R01 HL081420/HL/NHLBI NIH HHSUnited States/ ; R01 ES016769/ES/NIEHS NIH HHSUnited States/ ; R21 AI114220/AI/NIAID NIH HHSUnited States/ ; P30 ES017885/ES/NIEHS NIH HHSUnited States/ ; R01 ES014677/ES/NIEHS NIH HHSUnited States/
• Volume:
  122
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f462a58682a6b696b92bb8ccc13076c9e8eacca48af975b4ab76902a5aea33e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/76267/cdc_76267_DS1.pdf
• File Type:
  [PDF - 890.78 KB ]