Details:

Alternative Title:
J Asthma
Personal Author:
Wunschel, Javen ; Poole, Jill A.
Wunschel, Javen ; Poole, Jill A. Less -
Description:
Objective

Recent studies have made advances into understanding the complex agriculture work exposure environment in influencing asthma in adults. The objective of this study is to review studies of occupational agricultural exposures including dust, animal, and pesticide exposures with asthma in adult populations.

Data Sources

PubMed databases were searched for articles pertaining to farming, agriculture, asthma, occupational asthma, airway inflammation, respiratory disease, lung disease, pesticides and organic dust.

Study Selections

Studies chosen were published in or after 1999 that included adults and asthma and farming/agricultural work or agricultural exposures and airway inflammatory disease measurements.

Results

The data remains inconclusive. Several retrospective studies demonstrate agricultural work to be protective against asthma in adults, especially with increased farming exposure over time. In contrast, other studies find increased risk of asthma with farming exposures, especially for the non-atopic adult. Mechanistic and genetic studies have focused on defining the wide variety and abundance of microorganisms within these complex organic dusts that trigger several pattern recognition receptor pathways to modulate the hosts’ response.

Conclusion

Asthma risk depends on the interplay of genetic factors, gender, atopic predisposition, type of livestock, pesticide exposure, and magnitude and duration of exposure in the adult subject. Longer exposure to occupational farming is associated with decreased asthma risk. However, studies also suggest that agricultural work and multiple types of livestock are independent risk factors for developing asthma. Prospective and longitudinal studies focusing on genetic polymorphisms, objective assessments, and environmental sampling are needed to further delineate the influence of agriculture exposure in the adult worker.


Subjects:
[+]
Adaptive Adult Agriculture Animals Article Asthma Dust Farm Humans Immunology Inflammation Innate Lung Occupational Exposure Pesticides Risk Factors
Source:
J Asthma. 53(5):471-477
Pubmed ID:
26785925
Pubmed Central ID:
PMC4946797
Document Type:
Journal Article
Funding:
R01 ES019325/ES/NIEHS NIH HHSUnited States/ ; U54 OH010162/OH/NIOSH CDC HHSUnited States/
R01 ES019325/ES/NIEHS NIH HHSUnited States/ ; U54 OH010162/OH/NIOSH CDC HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:074b19f3e6473db47c23b07c49274b450e7d38ccc87597cadd4b0df40d090588
Download URL:
https://stacks.cdc.gov/view/cdc/75900/cdc_75900_DS1.pdf
File Type:

Supporting Files

• nihms801571.nxml

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